DSA引导下鱼肝油酸钠泡沫硬化剂治疗下肢静脉曲张临床应用价值.docVIP

DSA引导下鱼肝油酸钠泡沫硬化剂治疗下肢静脉曲张临床应用价值 　　[摘要] 目的 探讨国产鱼肝油酸钠自制成泡沫硬化剂治疗下肢静脉曲张的临床疗效。方法 选择我院39例（52条患肢）下肢静脉曲张的患者，在DSA引导下，曲张静脉注射自制鱼肝油酸钠泡沫硬化剂，观察下肢曲张静脉的闭合情况。结果 52条患肢在DSA引导下均成功注射泡沫硬化剂，平均每条患肢应用5.5mL（3.0～8.0mL）泡沫硬化剂。47条患肢（90%）下肢静脉治疗后即刻可见血流消失。3个月后随访血管超声示：49条患肢（95%）曲张静脉闭塞，无严重并发症发生。结论 DSA引导下鱼肝油酸钠自制成泡沫硬化剂治疗下肢静脉曲张的临床效果满意，是微创治疗下肢静脉曲张的新方法。 　　[关键词] 静脉曲张；鱼肝油酸钠；硬化疗法；泡沫硬化剂 　　[中图分类号] R654.4 [文献标识码] B [文章编号] 1673-9701（2011）34-145-02 　　 　　Clinical Effect of DSA-guided Foam Sclerotherapy of Sodium Morrhuate in Treatment of Lower Extremity Varices 　　WANG Haiting1 JIANG Zhongpu1 ZHOU Yi1 ZHANG Yanjun1 JIANG Qiang1 LIU Yuwei2 WANG Baoshou2 　　1.Department of Intervention，The First Peoples Hospital of Kaifeng City in Henan Province，Kaifeng 475000，China；2.Department of Vascular Surgery，The First Peoples Hospital of Kaifeng City in Henan Province，Kaifeng 475000，China 　　 　　[Abstract] Objective To study the clinical effect of lower extremity varices treated with foam sclerosants produced extemporarily from sodium morrhuate. Methods All of 39 cases（52 lower limbs）with lower extremity varices treated using sodium morrhuate foam sclerosants under DSA-guided were assessed to observed the occlusion of the saphenous veins in the following 3 months. Results The procedure was technically successful in all 52 patients. Foam sclerosant doses ranged from 3.4mLto 8.2mL per patient，with an average dose of 5.9 mL. 47limbs（90%）showed the instantly vanish. 49 varical limbs（95%）showed occlusion with vascular ultrasound during the next 3 month follow-up and there was no serious complication taken palace. Conclusion The clinical effect of fluoroscopy-guided foam sclerotherapy of lower extremity varices with sodium morrhuate was satisfactory. The method could be a new micro-trauma treament approach for this disease. 　　[Key words] Varicose veins；Sodium morrhuate；Sclerotherapy；Foam sclerosant 　　 　　近几年，泡沫硬化疗法对大隐静脉曲张的治疗因微创、有效、简单而在欧洲国家有较多应用报道。目前制备泡沫硬化剂的液体中，应用最多的是聚乙二醇单十二醚和十四羟基硫酸钠等，国内尚无有效的替代品，而国产鱼肝油酸钠化学成分与聚乙二醇单十二醚相同。本文对我院2