妊娠期糖代谢异常危险因素分析.docVIP

妊娠期糖代谢异常危险因素分析 　　[摘要] 目的：探讨妊娠期糖代谢异常发病的危险因素，为临床预防提供理论依据。方法：对135例妊娠期糖代谢异常孕妇和135例健康孕妇，采用统一的调查表进行调查，调查内容包括糖尿病家族史、高血压病史、吸烟史、饮酒史、饮食、体重、既往孕产史等进行对照研究。结果：多因素logistic回归分析显示糖尿病家族史、年龄＞25岁、孕前腰臀比＞0.9和高尿酸血症是妊娠期糖尿病发病的独立危险因素。结论：年龄＞25岁、有家族糖尿病史、孕前腰臀比＞0.9、孕前存在高尿酸血症的孕妇应早期进行妊娠期糖尿病筛查。 　　[关键词] 妊娠期糖代谢异常；妊娠期糖尿病；Logistic回归分析；危险因素 　　[中图分类号] R714.14+7 [文献标识码] C [文章编号] 1673-7210（2011）06（c）-150-02 　　 　　Analysis of hazard factor of gestational sugar metabolic anomalies 　　LIANG Yunyi, CHEN Youping, ZENG Chunping, SHU Yi, PAN Miao, LIU Shuai 　　Department of Endocriology, the Peoples Hospital of Nanhai District in Foshan City, Guangdong Province, Foshan 528000, China 　　[Abstract] Objective: To discuss hazard factor of gestational sugar metabolic anomalies morbidity during gestation period, provides the theory basis for the clinical prevention. Methods: 135 cases of sugar metabolism disorders pregnant women and 135 cases of healthy pregnant women, adopt uniform questionnaire investigation, the survey contents include diabetes family history, history of hypertension, smoking history, drinking histories, diet, weight, always pregnant production history, etc. Control study was made. Results: By the multi-factor logistic regression analysis in diabetes family history, the age25 year old, before being pregnant, waist-to-hip ratio0.9, the hyperuricemia was the independence hazard factor of GDM morbidity. Conclusion: Pregant women with the age25 year old, waist-to-hip ratio0.9, the hyperuricemia and hypertriglyceridemia should carry on gestational diabetes screening early. 　　[Key words] Gestational sugar metabolic anomalies; Gestational diabetes; Logistic regression analysis; Hazard factor 　　 　　妊娠期糖代谢异常包括妊娠期糖尿病（gestational diabetes mellitus, GDM）和妊娠期糖耐量受损（gestional impaired glucose tolerance, GIGT），是妊娠期最常见的产科并发症之一，其中GDM??指在妊娠期发生或在妊娠期才首次发现的糖尿病[1]。GDM可导致妊娠高血压综合征、剖宫产及产后糖尿病的发病率明显升高，并且可以导致胎儿宫内窘迫、巨大胎儿等并发症[2]，而妊娠本身对糖代谢的影响也导致随着孕周的增加，GIGT可向GDM发展甚至转变为GDM。为研究妊娠糖代谢异常发病的相关因素，为预防妊娠糖尿病发生提供理论依据，本文采用1∶1病例对照研究调查了1