幽门螺杆菌感染在肝硬化并发症患者中分布状况调查.docVIP

幽门螺杆菌感染在肝硬化并发症患者中分布状况调查 　　[摘要] 目的 研究幽门螺杆菌（Hp）对肝硬化并发症患者的影响。 方法 本院279例肝硬化合并上消化道出血、肝性脑病、原发性肝癌均接受快速尿素酶试验和14C-尿素呼气试验进行Hp检测。 结果 Hp感染与肝硬化合并上消化道出血、肝性脑病、原发性肝癌有不同程度的关系，尤其Hp阳性组中消化性溃疡伴出血、肝性脑病、原发性肝癌发生率均高于Hp阴性组。 结论 肝硬化患者中Hp感染与肝硬化并发症相关，根除Hp可能降低上消化道出血、肝性脑病、原发性肝癌的发生。 　　[关键词] 幽门螺杆菌；肝硬化；上消化道出血；肝性脑病；原发性肝癌 　　[中图分类号] R575.2 [文献标识码] B [文章编号] 1673-9701（2012）01-036-02 　　 　　Investigation on the helicobacter pylori infection distribution in patients with liver cirrhosis 　　ZHENG Yang CHEN Lixi GE Haifeng ZHENG Kefei 　　The Third People’s Hospital of Yueqing City in Zhejiang Province，Yueqing 325604，China 　　 　　[Abstract] Objective To study the effect of helicobacter pylori infection in patients with hepatic cirrhosis-related complications. Methods Hp was examined in hepatic cirrhosis group of 279 patents with upper gastrointestinal hemorrhage, hepatic encephalopathy and primary liver carcinoma in our hospital by rapid urea test and 14C urea breath test. Results There were different degrees of relationship between Hp infection and hepatic cirrhosis group with upper gastrointestinal hemorrhage, hepatic encephalopathy and primary liver carcinoma，which particularly the incidence of peptic ulcer with hemorrhage，hepatic encephalopathy and primary liver carcinoma in Hp positive patients were higher than in Hp nengative patients. Conclusion Hp infection in patients with cirrhosis is related to hepatic cirrhosis-related complications，and Hp eradication may reduce upper gastrointestinal hemorrhage, hepatic encephalopathy and primary liver carcinoma. 　　[Key words] Helicobacter pylori；Hepatic cirrhosis；Upper gastrointestinal hemorrhage；Hepatic encephalopathy；Primary liver carcinoma 　　 　　肝硬化是一种常见由不同病因引起的肝脏慢性、进行性、弥漫性病变，随着病情发展可出现不少并发症，如肝性脑病、上消化道大出血、原发性肝癌等，往往因此死亡，而幽门螺杆菌（Hp）在肝硬化及并???症中扮演着重要的角色。本文通过本院对肝硬化并发症中幽门螺杆菌感染分布情况进行研究，旨在了解幽门螺杆菌对肝硬化病情发展的影响。 　　 　　1 资料与方法 　　1.1 一般资料 　　2005年8月～2011年6月住院患者，共279例，男159例，女120例，年龄38～67岁，平均（52.8±10.4）岁，合并上消化道出血176例，合并肝性脑病67例，合并原发性肝癌36例；所有患者排除存在肾、心、肺疾病及糖尿病，1个月内未服用H2受体拮