《慢阻肺copd精品》课件.pptVIP

总结 COPD本质是慢性炎症（气道和肺） 吸烟是COPD最重要的启动因素COPD特征是气流受限（不完全可逆） COPD标志性症状是气短 COPD诊断金标准靠肺功能（吸入支气管扩张剂后FEV1/FVC70%） COPD的治疗规范且不断进展 戒烟是唯一有效延缓肺功能下降的措施 欢迎大家来南方医院呼吸科参观学习！ * 慢性阻塞性肺疾病全球创议，global initiative for chronic obstructive pulmonary disease,GOLD 本图说明吸烟与COPD发病的密切关系。吸烟者COPD的累积发病率高达35.5%，而不吸烟者仅为 7.8%，且吸烟者中不同程度的COPD发病率皆比不吸烟者的高。以上数据皆提示吸烟能增加COPD的发病。 Key Point Smoking is associated with a higher incidence of COPD. Those who quit smoking have a lower incidence of COPD. L?kke et al examined the risk of developing COPD in a general population over a period of 25 years and analyzed this risk in relation to different amounts of tobacco smoked. All individuals included in this study participated in the Copenhagen City Heart Study, which is a longitudinal study of several thousand individuals from the city of Copenhagen in Denmark. The data used were taken from the 4 examinations of the Copenhagen City Heart Study; 14,223 individuals went to the first examination, which was conducted from 1976 to 1978. Men and women (N=8045) aged 30 to 60 years with normal lung function who were nonasthmatics and who had adequate smoking data were chosen from this group and followed up for 25 years. Spiromety was checked at baseline and subsequently 3 additional spirometric examinations were done during the 25 years. This enabled the investigators to monitor for the development of COPD. Data on mortality came from the Danish Death Register. At the fourth examination, which was conducted between 2001 and 2003, all subjects reported whether they were current smokers, ex-smokers, or never smokers. Using this information, the investigators defined the following subgroups: Never smokers Ex-smokers (stopped smoking before enrollment) Early smoking cessation (stopped smoking between the first and second surveys) Intermediate smoking cessation (stopped smoking between the second and third surveys) Late smoking cessation (stopped smoking between the third and fourth surveys) Continuous smokers (con