自主神经系统药物.pdfVIP

肾上腺素受体激动药 （adrenocepter agonists） 拟交感胺类药 （sympathomimetic amines） 拟肾上腺素类药 zl （adrenomimetic drug） zl zl zl Adrenergic agonists Groups Drugs αR agonist α α R Noradrenalin metaraminol 1 2 agonist α R agonist Phenylephrine methoxamine 1 αR agonist clonidine 2 β R agonist zl β β R Isoprenaline 1 2 agonist β R dobutamine 1 agonist salbutamol β R agonist 2 Quick review αreceptor： 1 contracts βreceptor：heart function 1 enhancement βreceptor： 2 zl bronchial smooth muscles: relaxation skeletal muscle vessels: relaxation Adrenomimetic drugs adrenoceptor agonists zl β--phenylethylamine 称儿茶酚胺类 Adrenomimetic drugs adrenoceptor agonists Commonness 1 Basic structure :β-- phenylethylamine 2 Main effects in the cadiovascular systerm zl 3 Elimination from uptake, MAO, COMT 4 Main application: shock zl zl Adrenomimetic drugs adrenoceptor agonists Individuality 1 Structure: different substituted groups 2 Different of receptor zl selectivity 3 Different effects mostly on the systolic and diastolic blood pressure (pulse pressure) Adrenomimetic drugs R heart PVR BP other effec t adrenaline