saframycin c的全合成及醛胺类硫化促进剂工艺研究-study on the total synthesis of saframycin c and the process of aldehyde amine vulcanization accelerator.docxVIP

AbstractThis paper is divided into two parts. The first part is the synthesis of Saframycin C tetrahydroisoquinoline alkaloids. The the separation, activities and synthesis of complex tetrahydroisoquinoline alkaloids was description, On this basis, Saframycin C was selected as the target, and the way of its total synthesis was explored. 3-methyl catechol, vanillin, and the R/S configuration serine were selected as the starting material and multi-step reaction synthesis was to build the key intermediate of complex tetrahydroiso-quinoline alkaloids which have five fused ring nucleus, the structure was confirmed by 1H NMR and 13C NMR. With optimization condition and screening of the synthetic strategy ,the synthesis of key intermediate was completed in high yield.The second part is the aldehyde amine rubber vulcanization accelerator synthesis technology. We have a research on small test process to synthetic of two important kinds of rubber vulcanization accelerator DHP and 808. Compared with the original synthetic methods, the new technology with high yield, mild conditions, easy operation, low-cost industrial production becomes possible.Keywords: Tetrahydroisoquinoline; Saframycin C; total synthesis; thiofide; process research目 录摘要 ............................................................................ IAbstract ........................................................................ II第一部分 四氢异喹啉啉生物碱 Saframycin C 关键中间体的合成11 文献综述 ...................................................................... 11.1 引言 .................................................................... 11.2 四氢异喹啉类生物碱概述................................................... 4Saframycins 类生物碱5Naphthyridinomycins 类生物碱 11Quinocarcins 类生物碱 131.3 四氢异喹啉类生物碱的生理活性及抑癌机理.................................. 151.4 国内外 Saframycins 类四氢异喹啉类生物碱的研究现状 16国外对 Saframycins 类生物碱的合成研究 16国内对 Saframycins 类生物碱的合成研究 281.5 研究的目的与意义........................................................ 302 四氢异喹啉生物碱(-)-Safra