血清半胱氨酸蛋白酶抑制剂c与进展性脑梗死的相关性分析-correlation between serum cystatin c and progressive cerebral infarction.docxVIP

AbstractBackground and Objective:According to recent epidemiological data, cerebrovascular disease is the second cause of death in China. In many cities, it has become the first cause of death. A lot of survivors have disabilities. As a type of cerebral infarction, the progressive ischemic stroke results inprogressive neurological disorder, and finally can cause severe neurological impairment, disability and mortality. It was founded that Cysteine proteinase inhibitor C (Cystatin C, CysC) has the strongest inhibitory effect on cathepsin recently. Interaction with cathepsin and CysC, maintains the dynamic balance of sedimentation and degradation in excellular matrix. Once the balance is broken, it would accelerate the process of atherosclerosis. The aim of this study is to found out CysC in the role of progressive ischemic stroke, the relationship between CysC and associated risk factors, assess the early diagnosis of progressive cerebral infarction, prognosis by using CysC. This study is trying to provide some relevant information for clinical early detection, prevention and treatment of progressive cerebral infarction.Methods:This study selects 268 patients with acute cerebral infarction from June 2011 to December 2012 at Department of Neurology, the Second Affiliated Hospital of Shantou University Medical College. According to cerebral infarction whether progressed after admission,the patients were divided into progressive ischemic stroke group,90 cases ,and non-progression group, 178 cases. Select another 108 patients without cerebral infarction as normal control group. All the patients were quantified the neurological deficit level of patients on admission with U.S. National Institutes of Health Stroke Scale; Recorded gender, age, national, history of hypertension, diabetes history and smoking, alcohol abuse history; Checked and recorded the laboratory indicators, including serum CysC, fasting blood glucose, total cholesterol, triglycerides, high den