一元反应型二氧化氯固体制剂的制备分析-preparation and analysis of mono - reactive chlorine dioxide solid preparation.docxVIP

中北大学学位论文 中北大学学位论文 用β-环糊精作为粘结剂压片时，片剂的硬度和脆碎度可满足要求；以碳酸氢钠为发泡 剂，可有效的促进片剂溶解，并对二氧化氯的产生起到促进作用；采用包衣技术可有 效的增加片剂的稳定性，得到较好的效果。 ⑷ 依据《中国药典2005年版》和卫生部2005版《消毒技术规范》对制备的亚氯酸 钠-活化体系片剂的相关性能进行分析。分析得到：该片剂的平均片重为0.1548g，各片 二氧化氯的平均含量为6.867mg（于水中反应30min后），片重差异在-4.65%~6.91%之 间，平均硬度和脆碎度分别为38.78N和0.56%，且平均崩解时限为655s；该片剂于水中 反应30min后，溶液的pH值为2.7，片剂的活化率达到77.71%；将该片剂于湿度为70% 的54℃烘箱内放置14d后，二氧化氯的下降为8.77%，即有效贮存期达到1年。 关键词：反应型，二氧化氯，包合物，片剂，性能分析 The Preparetion Study on Response-type Solid Chlorine Dioxide Disinfection Paked in Singal-Ingredient ABSTRACT Chlorine dioxide gas is so active and unstable that it is difficult to make into compressed gas. And the liquid chlorine dioxide is too volatile to concentrate. So the use of chlorine dioxide is limited. Stabilized chlorine dioxide solution has many disadvantages, such as the content of water is too much, low effective constituent of chlorine dioxide, and needing to add acid activator, ect. In this article, we presented the preparation and research of solid chlorine dioxide. Because sodium chlorite and solid acid could react to generate chlorine dioxide, so mangy experiments have been done confirm the best ingredients of the activate system. In the research, the different mass ratios of sodium chlorite and active system have been discussed by activate effectiveness. The active system was constituted by acidifier, activator, passivator. At last, We have obtained:①It could get satisfactory effect when adopt acid X and acid Y as acidification agent, and the mass ratios of the two acids with sodium chlorate were both 5:3. ②In the system of acid X, when using activator A as activator, the conversion of sodium chlorate was the largest, and the mass ratio of sodium chlorite with activator A was 1:1.③In the system of acid Y, activator B had the best effect of activation, and the best effect happens when the quality ratio was 5:3.④The stability of the system could get certain security when using magnesium sulfate and calcium chloride as passivator. Because of the β-C