一种纳米药物对耐药结核分枝杆菌的作用及机制分析-effect and mechanism analysis of a nano drug on drug-resistant mycobacterium tuberculosis.docxVIP

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一种纳米药物对耐药结核分枝杆菌的作用及机制分析-effect and mechanism analysis of a nano drug on drug-resistant mycobacterium tuberculosis.docx

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一种纳米药物对耐药结核分枝杆菌的作用及机制分析-effect and mechanism analysis of a nano drug on drug-resistant mycobacterium tuberculosis

Effect and mechanism of a kings of drug medicinal namoparticles A、B、C、D for drug-resistant of Mycobacterium tuberculosisAbstract:Objective: In this study we choosed medicinal namoparticles as a carieer in order to make A、B、C、D into medicinal namoparticles A’、 B’、C’、D’ to explore the effect and mechanism of drug-resistant ofMycobacterium tuberculosis. Methods: (1) A、B、C、D were encased in medicinal nanoparticles to make them to be medicinal nanoparticles A’、B’、C’、D’ with the help of four constant temperature magnetic stirrer;(2) To identify tuberculosis mycobacterium type we used Acid roche drug sensitive medium and gene chip technology , then we selected sensitive strain H37Rv and three resistant strains (respectively, resistant to isoniazid, rifampicin and multi-drug resistant strains) as experiment object; (3) The experiment was made up of experimental group and thecontrol group, experimental group 1: Medicinal nanoparticles A、B、C、D; experimental group 2: A、B、C、D; experimental group 3: experimentalgroup 1 and experimental group 2 respectively combined with INH; experimental group 4: experimental Group1 and experimental group 2 respectively in joint RFP. The experimental group 1, group 2 and group 3 and group 4, respectively affected the four kinds of TB strains.Thecontrol group was composed of positive control group、 negative controlgroup and blank control group. Positive control group:INH and RFPrespectively affected the four kinds of TB strains. Negative control group ： Four strains of mycobacterium tuberculosis bacterium fluid group.Blankcontrolgroup:Mie7H9culturesolution. (4)Firstly,medicinal namoparticles A、B、C、D as well as A’、B’、C’、 D’ respectively affected on the four kinds of TB strains.Then, the medicinal namoparticles A’、B’、C’、D’ as well as A、B、C、D respectively combined with INH or RFP to affect on the four kinds of TB strains.Finally,with the help of MTT method we investigated the effect of each kind of strai