2型糖尿病脂联素水平变化意义及多因素分析.docVIP

2型糖尿病脂联素水平变化意义及多因素分析 　　【摘要】 目的 观察2型糖尿病(T2DM)患者脂联素水平变化，比较不同体重指数(BMI)者脂联素水平差异，探讨其与糖尿病的关系，并对受其影响的相关因素进行相关性分析。方法 将77例T2DM患者分为非肥胖组26例(NF组)，肥胖组51例(F组)。另取18例正常体检者作为对照(N组)。分别采用ELISA法检测脂联素，放射免疫法检测连接肽(CP)，采用TOSHIBA TBA?120FR全自动生化仪检测空腹血糖(FPG)、血脂、C反应蛋白(CRP)。结果 所有T2DM患者血浆脂联素水平均显著低于正常人(P＜0.01)；F组血浆脂联素明显低于NF组(?P?＜0.01)；简单典型相关性分析结果显示，除NF组脂联素与MBp无显著相关性，F组和所有T2DM者的脂联素与TG及FPG亦无显著相关性之外，其他因素与脂联素均呈显著负性相关(P＜0.01)。多元线性回归分析结果显示，所有T2DM者LDLC、CP、MBp与脂联素相互影响有显著性意义(?P＜0.05或0.01)；NF组LDL?C、CP、BMI与其相互影响意义有显著性(?P?＜0.05)；而F组LDL?C、BMI、MBp与其相互影响有显著性意义(?P?＜0.05或0.01)。结论 血浆脂联素水平降低是T2DM、高血脂、肥胖、高血压的重要危险因素，血浆脂联素在T2DM、高血压、高血脂等发病中起重要作用。 　　【关键词】2型糖尿病；脂联素；低密度脂蛋白胆固醇；体重指数；C肽? 　　文章编号：1003-1383(2007)06-0623-04中图分类号：R 587.1 文献标识码：A? 　　 　　The variances of adiponectin and the associating factors analysis ? 　　in patients with type 2 diabetes mellitus 　　CHEN Kuan?lin?1，ZHOU Qing?2，WANG Jian?3? 　　(1.Medicine Teaching and Research Section of Jiangsu Staffs Medical University, NanJing,JiangSu?210029；2.Community Health Service Center of Qinhong District, NanJing,JiangSu 210001；?3.Community Health Service Center of Honghua District, NanJing,JiangSu210006)?? 　　 　　【Abstract】 Objective To study the variances of adiponectin in patients with type 2 diabetes mellitus (T2DM), compared them by body mass index(BMI) and investigate the relation with diabetes,then detected the serum levels of adiponectin and analysed the associating factors.Methods 77 patients with T2DM were divided into two groups according to BMI:26 not fleshiness cases(group NF) and 51 fleshiness cases (group F). And there were 18 normal cases in control group.To all the cases,serum adiponectin were detected by ELISA;low density lipoprotein cholesterol(LDLC),triglyceride(TG),C?reactive protein(CRP),fasting plasma glucose(FPG) were detected by TOSHIBA TBA?120FR automatically biochemical analyzer;connective peptide (CP) were detected by immunoradiometric assay(IRMA). Results Serum adiponetin levels in patients with T2DM were significant lower than those of