安宫牛黄丸对出血性中风大鼠实验研究.docVIP

安宫牛黄丸对出血性中风大鼠实验研究 　　摘要：目的研究安宫牛黄丸对出血性中风大鼠的影响。方法自发性高血压大鼠随机分为A组（空白对照组）、B组（模型组）、C组（西药治疗组）、D组（中药治疗组）、E组（中西结合治疗组），以自体血制作出血性中风大鼠模型，术后1 d、2 d、3 d分别进行神经功能(肌力测验、平衡木行走试验) 及血常规和凝血功能的测定。结果术后各组之间血常规、凝血功能差异无统计学意义（P0.05），B组大鼠神经功能缺损较A组高（P 　　关键词：安宫牛黄丸 出血性中风 神经功能 凝血功能 　　中图分类号：R743.3R285.5文献标识码：A文章编号：1672-1349(2011)05-0574-03 　　Effect of Angong Niuhuang Pill on Hemorrhagic Stroke in Rats 　　Zhang Yunqiao，Liu Yuanxin // Xinjiang Medical University（Urumqi 830054） 　　Abstract:ObjectiveTo study the effect of Angong Niuhuang pill on hemorrhagic stroke in rats.MethodsOne hundred and thirty spontaneously hypertensive rats were randomly divided into five groups:Group A (blank control group)，group B (model group)，and group C (western medicine treatment group).group D (Chinese medicine treatment group)，group E (integrated Chinese medicine and western medicine treatment group).Rat models with hemorrhagic stroke were established by injecting of auto-non- anticoagulated artery blood into the caudate nucleus.Nerve function (beam-walking test and bilateral forepaws grasp) was tested at 24 hours，48 hours and 72 hours after operation.The blood routine test and coagulation function were also tested at 72 hours after operation.ResultsThere was no significant difference in aspect of the blood routine test and coagulation function between different groups after operation (P0.05).Neurological deficit in Group B was higher than that in group A after operation (P0.05).ConclusionAngong Niuhuang pill could improve the ability of balancing，grasping，walking and limb muscle strength in rats with hemorrhagic stroke，but it had no significant effect on blood routine test and coagulation function. 　　Key words:Angong Niuhuang pill；hemorrhagic stroke；nerve function；coagulation function 　　 　　脑卒中因其起病急骤，证见多端，变化迅速，犹如自然界的风善行而数变，故在中医又称中风。对于中风的记载，始见于《黄帝内经》，出血性中风属现代医学概念，是在中医学中???病基础上的进一步延伸，深化了对其病理实质的了解。中医药干预出血性中风病的疗效已为多年的临床所证实，但是目前国内出血性中风的中医药研究多以临床研究为主，而具有重复性、随机对照的动物实验性研究较少，已成为阻碍中医出血性中风病规范化治疗的瓶颈。本研究通过在自发性高血压大鼠上建立出血性中风模型，