帕罗西汀合并认知疗法治疗酒依赖伴发抑郁及对戒酒影响.docVIP

帕罗西汀合并认知疗法治疗酒依赖伴发抑郁及对戒酒影响 　　【摘要】 目的 评价帕罗西汀合并认知疗法治疗酒依赖伴发抑郁的疗效及对戒酒 的影响。方法 将98例酒依赖伴发抑郁的患者随机分为研究组和对照组，分 别用认知疗法合并帕罗西汀、单用帕罗西汀治疗4个月。用汉密顿抑郁量表(HAMD)评定疗效 ；用复饮率评定戒酒效果。结果 治疗1个月后，研究组HAMD评分16.79±6. 50与对照组相近17.88±6.59(P0.05)。治疗4个月后HAMD评分10.76±5.32 、明显低于对照组14.54±5.12(P 　　【关键词】 认知疗法；帕罗西汀；酒依赖；抑郁 　　 　　A Comparative Study of Paroxetine Plus Cognitive Therapy in the Treatment of Alc ohol Dependent Patients with Depression Disorder and Effect of Withdraw Alcohol.Huang Chengfan, Pan Runde, Zhou Weidong, et al. Guangxi Longquanshan Ho spital, Liuzhou 545005, P.R.China 　　【Abstact】 Objective To investigate the effect of Paroxetine plus cog nitive therapy in the treatment of Alcohol dependent patients with depressive di sorder and the with-draw alcohol. Methods The 98 Alcohol depen dent patients with depressive disorder were randomly divided into treatment grou p and control group, the treatment group were given Paroxetine plus cognitive th erapy, the control group were given Paroxetine during treatment of 4 months. Theeffect was assessed by Hamailton Depression Rating Scale(HAMD) and rate of re- drinking. Results The sco nes of HAMD ware no significant differences between two groups after 1 month. Th e scones of HAMD of the treatment group were significantly lower than that of th e control group after 4 month; The effect in the treatment group was significant ly better than that of the control group; rate of re-drinking is lower than tha t of the control group. Conclusion Paroxetine plus cognitive the rapy has bettereffect on treatment of Alcohol dependent patients with depressive disorder and w ithdraw alcohol. 　　【Key words】 Cognitive therapy; Paroxetine; Alcohol dependence; Depres sive disorder 　　 　　陈仁德等研究发现，63.2%住院酒依赖患者存在明显的抑郁情绪[1]。国外研究表明 用舍曲林合并合认知行为治疗酒依赖伴发抑郁，抑郁的改善和预防酒依赖复饮均比单用舍曲 林有效[2]。但是，目前国内尚未发现用帕罗西汀合并认知疗法治疗酒依赖伴发抑 郁及对戒酒影响的报道。为此，我们用认知疗法合并帕罗西汀治疗酒依赖伴发抑郁，与单用 帕罗西汀治疗作对照比较，了解其疗效及戒酒效果。 　　 　　1 对象与方法 　　 　　1.1 对象 2004年10月～2006年6月在广西龙泉山医院住院治疗30～40天，以后在门诊就医 的酒依赖患者。入组标准：①符合CCMD-3酒依赖综合征的诊断