早产儿血清胱抑素浓度及影响因素临床研究.docVIP

早产儿血清胱抑素浓度及影响因素临床研究 　　[摘 要] 目的 为了研究早产儿血清胱抑素（Cystatin C，cys-c）的浓度及临床影响因素和临床意义。方法 对我科NICU 2007年1～7月住院的出生48小时以内]、孕龄和出生史明确的早产儿80例，分别于生后24～48小时内进行血清cys-c和血红蛋白测定；同时摘记早产儿的相关临床资料：性别、出生体重、出生胎龄、分娩方式、出生Apgar评分、孕母年龄和孕母孕期合并症。 结果 ①早产儿血清cys-c平均值为（1.82±0.4514）mg/L，明显高于成人水平（0.81±0.22）mg/L (t=20.0127,p 　　关键词：早产儿 血清胱抑素 影响因素 　　 　　Clinical Study on Influencing Factors of Serum Cystatin-C in Preterm Infants 　　[Abstract] Objective To study the influencing factors and clinical significances of serum Cystatin- C (cys-c) in preterm infants. Methods 80 preterm infants who were Hospitalized newborn intensive care unit (NICU) within born 48 hours , gestation age and birth history conclusive from January to July in 2007,whose serum cys-c and hemoglobin were detected within born 24-48 hours ; and relevant clinical data ,of which were born weight, sex,gestation age, delivery mode, Apgar evaluation, hemoglobin level, pregnancy age and health status during pregnancy, were taken notes at the same time.Results Serum cys-c levels in preterm infants were higher than that of adults, with a mean of (1.82 ± 0.4514)mg/l (t=20.0127,p0.05).Conclusions 　　Serum cys-c levels in preterm infants were higher than that of adults, and born weight,sex, gestation age, delivery mode, Apgar evaluation, hemoglobin level, pregnancy age and health status during pregnancy had no influence on it respectively. 　　[Kay words] preterm infant; cys-c; influencing factor 　　中图分类号：R722 文献标示码：B 文章编号：1005-0019（2008）3-0010-03 　　 　　早产儿生后各组织器官的功能均不成熟，肾脏功能的发育亦不成熟，肾小球的滤过率和肾小管的分泌功能均未达正常。同时，有一部分早产儿出生时受到一定危险因素的伤害，各组织器官的功能受损，肾脏的功能也同样受到损伤。早产儿的肌肉发育差，血清肌苷（SCr）参考值含量较低，测定误差相对较大。为了寻找一种参考值能更好的来反映早产儿肾功能的发育和损伤程度，同时也为了分析早产儿血清cys-c值的临床影响因素和临床意义。因此，我们对80例出生24-48小时内的早产儿进行血清cys-c的测定。现将检查结果报告如下： 　　 　　1 资料与方法 　　 　　1.1 一般资料 　　我科NICU2007年1月～7月住院的48小时以内、孕龄和出生史明确的早产儿80例，其中男45例，女35例；胎龄＜32周9例, 32～34周33例, 34～37周38例；出生体重＜1.5公斤6例，1.5～2.0公斤31例,2.0～2.5公斤31例，≥2.5公斤12例；出生Apgar评分＜7分24例，≥7分56例；产道分娩43例，剖宫产分娩37例；血红蛋白值＜150g/L20例，150～200g/L55例，≥200g/L5例；孕母年龄＜25岁29例