早产适于胎龄儿低钠血症预防研究.docVIP

早产适于胎龄儿低钠血症预防研究 　　[摘要] 目的:探讨早产适于胎龄儿低钠血症的早期预防。方法:对151例早产适于胎龄儿(PAGA)血清Na+进行动态检测,将其随机分为三组:A组51例,B组54例,C组46例。A、B组分别于生后24、48 h开始静脉泵注Na+ 2～3 mmol/kg,C组生后72 h内不补Na+。生后即时及生后满72 h,查血清Na+。结果:生后即时血清Na+均在130～150 mmol/L。72 h后,血清Na+150 mmol/L。结论:早期预防,可降低早产适于胎龄儿低钠血症的发生率,且无导致高钠血症的危险性。 　　[关键词] 早产适于胎龄儿;低钠血症;早期预防 　　[中图分类号] R722.6 [文献标识码]A [文章编号]1674-4721(2010)04(a)-035-02 　　 　　Research on the prevention of Hyponatremia in premature infants appropriate for gestational age 　　WU Junchao,LIU Junmin 　　(Maternal and Child Health Hospital of Suizhou, Suizhou441300, China) 　　[Abstract] Objective: To discuss the early prevention of hyponatremia in premature infants appropriate for gestational age. Methods: Dynamic testing of serum Na+ on 151 cases of preterm infant appropriate for gestational age (PAGA). They were randomly divided into three groups, A group of 51 cases, B group of 54 cases and C group 46 cases. A and B groups were started intravenous infusion of Na+ for 2-3 mmol/kg at 24 hours、 48 hours after birth, respectively. C group didn′t supply Na+ within 72 hours after birth. Serum Na+ were tested immediately after birth and at 72 hours after birth. Results: Serum Na+ were at 130-150mmol/L immediately after birth. After 72 hours of serum Na+ 150 mmol/L. Conclusion: Early prevention can reduce the incidence of Hyponatremia in premature infants appropriate for gestational age,and there is no risk for hypernatremia. 　　[Key words] Premature infants appropriate for gestational age;Hyponatremia;Early prevention 　　 　　低钠血症是早产适于胎龄儿(premature appro-priate for gestaional age,PAGA)常见严重并发症,是导致PAGA中枢神经系统永久性损害,甚至死亡的原因之一[1-2]。如何预防PAGA低钠血症,却少见报道。2005年4月～2009年3月,笔者对本院分娩的151例PAGA血清Na+进行了前瞻性研究,旨在探讨PAGA低钠血症的早期预防。现报道如下: 　　1 资料与方法 　　1.1 一般资料 　　2005年4月～2009年3月,本院共分娩8 217例活产婴,选其中151例(1.84%)PAGA为研究对象,并符合下列条件:①其母孕期???康;②无先天性出生缺陷及遗传性代谢疾病;③无产伤及窒息史;④生后即时血清Na+、血气分析正常;⑤3 d内无严重低钠血症症状。151例PAGA随机分成三组:A组51例,B组54例,C组46例。其并发症如新生儿呼吸窘迫综合征(RDS)、硬肿症、高胆红素血症等出现的例次,三组间对比差异无统计学意义。 　　1.2 方法 　　1.2.1 治疗方法所有PAGA生后均根据需