健脾补肾汤对环磷酰胺致小鼠骨髓抑制影响-effect of jianpi bushen decoction on bone marrow suppression induced by cyclophosphamide in mice.docxVIP

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健脾补肾汤对环磷酰胺致小鼠骨髓抑制影响-effect of jianpi bushen decoction on bone marrow suppression induced by cyclophosphamide in mice.docx

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健脾补肾汤对环磷酰胺致小鼠骨髓抑制影响-effect of jianpi bushen decoction on bone marrow suppression induced by cyclophosphamide in mice

distinct increase in the value of CD3+, CD4 +, CD4 + /CD8+ and a clear decrease in the value of CD8+ in the high does jianpi bushen decoction group(P0.05); middle dose group increased CD4+ obviously; normal group CD4+ / CD8+ ratio higher than model group (P0.05).4. The influence on serum IL-6 effects: the value of IL-6 went up in all jianpi bushen decoction groups, but there is no statistical difference between each jianpi bushen decoction group, compared with the model group were significantly (P0.05). Compared with the control group, jianpi bushen decoction high dose group had a significantly increased role of IL-6 (P0.05).Conclusion: within the range of certain dosageJianpi bushen decoction has an good efficacy in treatment of bone marrow suppression of the mice caused by cyclophosphamide and enhance the innate immune systemof mice which have been through chemotherapy.Jianpi bushen decoction can increase the contents of IgG,IgM in the body of the immune suppression mice and regulate the hemopoiesis by humoral immunity.Jianpi bushen decoction can increase the value of CD3+,CD4+ and decrease thevalue of CD8+ in the body of the immune suppression mice, which indicate that the drug can enhance cellular immune and promote the function of regulating the hemopoiesis.Jianpi bushen decoction can stimulate the hematopoietic by elevating the level of IL-6 in the serum of the immune suppression mice.Key words: jianpi bushen decoction; bone marrow suppression; cyclophosphamide; immune缩略词表Abbreviations缩写IL-4英文全称Interlukin-4中文全称白细胞介素-4IL-10 IL-12 IL-6IFN-γDC PEInterlukin-10 Interlukin-12 Interlukin-6Interferon-γDendritiecells Phycoerythrin白细胞介素-10白细胞介素-12 白细胞介素-6 干扰素-γ 树突状细胞藻红蛋白RBCPLTRed blood cellPlatelet红细胞血小板EPO CAM FCM NKTGF-βELISA FITCPE-cy5 CSF ECM HGF HSC TGF TPO TNF CKThFlt3ErythropoitinCell adhesion molecule Flow cytometer Natural killer cellTransformating growth factor-βEnzyme linke Immunosobent assay Fluorescein isothiocyanate Phycoerythrin-cyanine blue pigmen