j第十章 甾体激素类药物的分析_PPT课件.pptVIP

To Sample compartment To Detector ０ λ/2 λ -λ/2 -λ Fixed Mirror(M2) Moving Mirror (M1) Source Beam splitter (Half Mirror) Interferometer Michelson interferometer Michelson Interferometer Fixed mirror Moving mirror X Beamsplitter Detector Polychromatic Radiation source 100% 50% 50% 50% 50% 25% + 25% 25%+ 25% (Michelson: 1890’s) A qualitative fingerprint check for the identity of raw material used in manufacture and for identifying drugs. Used in synthetic chemistry as a preliminary check for compound identity particularly for the presence or absence of a carbonyl group, which is difficult to check by any other method. Can be used to characterize samples in the solid and semi-solid states such as creams and tablets. Applications Used as a fingerprint test for films, coatings and packaging plastics. Can be used to detect polymorphs of drugs (polymorphs are different crystal forms of a molecule that have different physical properties such as solubility and melting point which may be important in the manufacturing process). Applications Oil Industry Pharmaceutical Industry Food Industry IR Forensic Science Materials Science Biological Science IR ...... ...... Environmental Science Polymers Semiconductors Ceramic Fields of IR Applications IR is one of the mostly widely used analytical techniques. IR can be used for both qualitative and quantitative analysis of any phase. Provides a complex fingerprint which is unique to the compound being examined. Computer control lf instruments means that matching of the spectrum of a compound to its standard fingerprint can now be readily carried out. Strengths Rarely used as a quantitative technique because of relative difficulty in sample preparation and the complexity IR spectra. Usually can only detect gross impurities in samples. Sample preparation requires a degree of skill, particularly when potassium bromide (KBr) discs are being prepared. The technique is lacking in robustness since