甲状腺自身抗体与反复自然流产关系研究.docVIP

甲状腺自身抗体与反复自然流产关系研究 　　摘 要 目的：评估甲状腺自身抗体(ATA)与反复自然流产(RSA)之间的关联。方法：采用电化学发光法对102例RSA患者血清进行抗甲状腺过氧化酶抗体(TPO-Ab)和抗甲状腺球蛋白抗体(TG-Ab)的检测，并以50例健康育龄妇女为对照。结果：RSA的患者中ATA总阳性率22.6%，明显高于正常对照组8.0%，RSA组中TPO-Ab和TG-Ab的阳性率分别为20.6%和15.7%，均显著高于正常对照组的6.0%和4.0%。早期流产组中的ATA总阳性率27.9%，与晚期流产组比较有明显的统计学上的差异，TPO-Ab和TG-Ab的阳性率分别为25.0%和19.1%，均显著高于正常对照组的11.8%和8.82%。2～3次或以上两组流产患者ATA的阳性率分别为32.4%和26.5%，两组间有统计学上的差异。结论：孕妇甲状腺自身抗体的存在与反复自然流产密切相关，甲状腺自身抗体可作为早期反复自然流产的监测指标。 　　关键词 甲状腺自身抗体 反复自然流产 TPO-Ab TG-Ab 　　doi:10.3969/j.issn.1007-614x.2012.01.132 　　Abstract Objective:To evaluate the relationship between thyroid antibodies(ATA)and repeated natural abortion (RSA).Methods:Test the thyroid peroxidase antibodies(TPO-Ab)and antithyroglobulin antibody(TG-Ab)in 102 cases of RSA patients serum using the method of electrochemical luminescence,keep 50 cases of healthy child-bearing age women as controls.Results:The total ATA positive rate in the patients of RSA was 22.6%,which is apparently 8.0% higher than the control group,TPO-and TG Ab-Ab positive rate in the RSA group were 20.6% and 15.7% respectively,both significantly higher than the 6.0% and 4.0%in the control group.the total positive rate ATA was 27.9% in the early abortion group,which was statistically significant different from that of the late abortion group,positive rate of TPO-Ab and TG-Ab were 25.0% and 19.1% respectively,significantly higher than the 11.8% and 8.82% than that of the normal control group.The positive rate of ATA patients of twice-abortion group was 32.4 and for the three or more than three-time sabortion group was 26.5%.theres statistical differences between the two groups.Conclusion:The repeated natural abortion closely related to the existence of pregnant womens thyroid antibodies,the thyroid antibodies can be the monitoring index to the early repeated natural abortion. 　　Keywords Thyroid antibodies;Repeated natural abortion;TPO-Ab;TG-Ab 　　反??自然流产(RSA)是妇产科较常见的并发症。原因有解剖、内分泌、感染、染色体、遗传等方面，其中40%～80%原因不明的可能与免疫因素有关??［1］?。通过测定RSA妇女与正常妇女血清中的ATA