阻塞性睡眠呼吸暂停低通气综合征与胃食管反流病关系.docVIP

阻塞性睡眠呼吸暂停低通气综合征与胃食管反流病关系 　　[摘要] 目的 探讨阻塞性睡眠呼吸暂停低通气综合征与胃食管反流病的关系。方法 150例成年阻塞性睡眠呼吸暂停低通气综合征患者中男性127例、女性23例,其中合并胃食管反流病者78例。对胃食管反流病和非胃食管反流病者的症状积分、睡眠呼吸紊乱指数、身体质量指数进行比较;同时对轻度、中度、重度阻塞性睡眠呼吸暂停低通气综合征患者的例数、症状积分进行比较。结果 具有胃食管反流病患者的上述三项指标均高于未诊断为胃食管反流病者;重度阻塞性睡眠呼吸暂停低通气综合征患者的例数较轻度和中度者高,但三者的症状积分无明显差别,经t检验,具有统计学意义(P 　　[关键词] 睡眠呼吸暂停低通气; 胃食管反流病; 症状积分; 呼吸紊乱指数 　　[中图分类号] R766.43 [文献标识码] A [文章编号] 1673-9701(2009)27-10-02 　　 　　Relationship of Obstructive Sleep Apnea-Hypopnea Syndrome with Gastroesophageal Reflux Disease 　　GAO Xiaoping REN Shouan ZHANG Zhenxia 　　Department of Respiratory,the First Hospital of Shanxi Medical University,Taiyuan 030001,China 　　 　　[Abstract] ObjectiveTo investigate the relationship between obstructive sleep apnea-hypopnea syndrome and gastroesophageal reflux disease. MethodsIn 150 adult patients with obstructive sleep apnea-hypopnea syndrome,127 was male and 23 was female,and 78 cases of the total were complicated with gastroesophageal reflux disease. Symptom score,apnea-hypopnea index(AHI) and body mass index(BMI)in these patients with and without gastroesophageal reflux disease were compared,and at the same time,the case number and the symptom score of mild,moderate and severe sleep apnea syndrome were analysed and compared. ResultsThe aboved-mentioned three item indexes in the patients with gastroesophageal reflux disease were all higher than those in the patients without gastroesophageal reflux diseasea,and the cases of severe sleep apnea syndrome were more than those of mild and moderate sleep apnea syndrome. There was no significant difference in the symptom score of mild,moderate and severe sleep apnea syndrome,but a significant difference in t test(P5次即诊断为OSAHS。OSAHS的病情程度判断[2]参考阻塞性睡眠呼吸暂停低通气综合征指南,轻度AHI 5～20,最低血氧饱和度(SaO2)≥86%;中度:AHI 21～40,最低血氧饱和度(SaO2)80%～85%;重度:AHI41,最低血氧饱和度(SaO2)≤79%。胃食管反流病以中华胃食管反流病研究组拟定的症状评分标准为依据[3]。(1)发作频率计分:按烧心感、胸骨后疼痛、反酸、反食等四种为统计症状,无症状为0分,症状出现频度 　　 　　3 讨论 　　 　　近年来,人们越来越明白OSAHS与GERD之间存在潜在联系,但是OSAHS与GERD的关系尚有争议。Heinemean