阿托伐他汀与胺碘酮联合治疗阵发性房颤疗效观察.docVIP

阿托伐他汀与胺碘酮联合治疗阵发性房颤疗效观察 　　[摘要] 目的 探讨阿托伐他汀联合胺碘酮治疗阵发性房颤的临床疗效。方法 选取阵发性房颤患者128例，随机分为两组。对照组患者在治疗原发病基础上，给予胺碘酮治疗，治疗组在对照组的用药基础上联合应用阿托伐他汀。随访12 个月，观察两组的疗效。结果 观察组总有效率明显高于对照组，差异有统计学意义（χ2=5.926，P＜0.05）。组间比较，治疗前两组左心房内径比较无差异（t=0.043，P＞0.05）；治疗后观察组左心房内径明显短于对照组，差异有统计学意义（t=6.521，P＜0.05）。结论 阿托伐他汀与胺碘酮联用能显著缩短左心房内径，显著减少房颤的复发和持续性房颤的发生。 　　[关键词] 阵发性房颤；阿托伐他汀；胺碘酮 　　[中图分类号] R541.7 [文献标识码] B [文章编号] 1673-9701（2011）31-75-02 　　 　　Clinical Observation of Atorvastatin Combined with Amiodarone in Treatment of Paroxysmal Atrial Fibrillation 　　LIU Ruitang1 ZHONG Weizi2 　　1.Taishan City Peoples Hospital in Guangdong Province，Taishan 529200，China；2.The Dispensary of Nanhai First Middle School of Foshan in Guangdong Province，Foshan 528252， China 　　 　　[Abstract] Objective To observe the effect of atorvastatin combined with amiodarone in the treatment of paroxysmal atrial fibrillation. Methods All 128 paroxysmal atrial fibrillation patients were randomly divided into two group.In the control group was given amiodarone on the basis of treatment the primary diseases.In the observation group was given atorvastatin on the basis of treatment the control group. Followed up 12 months，to observe the effect of the two groups.Results The total effective rates of the observation group was significantly higher than the control group. The differences were both statistically significant （χ2=5.926，P＜0.05）. Before the treatment，there was no significant difference in the left atrial diameter（LAD） between two groups. After treatment，the left atrial diameter（LAD） of the observation group was significantly shorter than the control group.The differences were significant（t=6.521，P＜0.05）.Conclusion The the left atrial diameter（LAD） was significantly shortened，recurrence of atrial fibrillation and the occurrence of persistent atrial fibrillation was decreased significantly 　　[Key words] Paroxysmal atrial fibrillation；Atorvastatin； Amiodarone 　　 　　 　　 　　阵发性房颤是指发病在72h内可以转复的房颤，是临床最常见的心律失常。随着时间的推移，常演变为持续性房颤和永久性房颤，且多数伴有左心