阿立哌唑与奥氮平治疗青少年精神分裂症对照研究.docVIP

阿立哌唑与奥氮平治疗青少年精神分裂症对照研究 　　【摘要】 目的：对比阿立哌唑与奥氮平治疗青少年精神分裂症临床疗效与安全性。方法：将58例青少年精神分裂症患者随机分为阿立哌唑组(29例)和奥氮平组(29例)进行对照研究，疗程8周。并于入组前，治疗后第1、2、4、8周采用阳性症状和阴性症状量表（PANSS）评定疗效，副反应量表（TESS）评定不良反应。结果：8周后，阿立哌唑组显效率为65.5％，有效率为86.2％，奥氮平组显效率为(68.9％)，有效率为(89.6％)，两组总体疗效差异无显著性意义(P0.05)。阿立哌唑组主要不良反应为兴奋或激越、震颤、静坐不能等，奥氮平组主要不良反应为体重增加、嗜睡等。结论：阿立哌唑治疗青少年精神分裂症是安全、有效的，不良反应少。 　　【关键词】 阿立哌唑；奥氮平；青少年精神分裂症 　　 　　A controlled study of Aripiprazole and Olanzapine in the Treatment of adolescent Schizophrenia. 　　Lu Qiang. 　　The Fifth People? Hospital of Nanning,Nanning 530001,China 　　【Abstract】 Objective To compare the efficacy and safety between Aripiprazole and olanzapine in the treatment of adolescent Schizophrenia. Methods Fifty-eight adolescent Schizophrenia were randomly divided into Aripiprazole group (Aripiprazole treatment) and olanzapine group(olanzapine treatment) for 8 weeks. Before and at the end of the 1st，2nd，4th and 8th week treatment，the efficacy was assessed with the positive and negative syndrome scale(PANSS)，and the side effect was evaluated by treatment emergent side effect scale(TESS). Results After 8weeks，there was no significant difference in the efficacy between the two groups(P＞0．05)．The significant efficacy rates of Aripiprazole was 65.5% and the total efficacy rate was 86.2% while that was 68.9%and 89.6% in the olanzapine group. The side effects of Aripiprazole group is agitation，remor，akathisia and olanzapine group is weight gain，somnolence.Conclusion Aripirazole is safe and effective in the treatment of adolescents schizophrenia and with few side effects. 　　【Key words】 Aripiprazole; olanzapine; Adolescents schizophrenia. 　　【中图分类号】 R749.3 【文献标识码】 Ｂ 【文章编号】 1007-8231（2011） 07-0286-02 　　 　　目前青少年精神分裂症多使用新型抗精神病药物治疗。而阿立哌唑是续第一代抗精神病药（FGA）及第二代抗精神病药（SGA）之后，对精神障碍治疗药理机制上具有革新性的新一代抗精神病药，又称为”第三代抗精神病药（TGA）” [1]，为验证其对青少年精神分裂症的疗效和安全性,笔者采用奥氮平为对照,现报道如下： 　　1对象和方法 　　1．1研究对象：病例来源于我院2010.1.1-2010.12.30的门诊和住院患者，均符合《中国精神疾病分类方案与诊断标准》第三版(CCMD-3)中精神分裂症标准诊断,年龄12-18岁，性别不限；阳性与阴性症状量表(PANSS)评分≥60分；排除严重的心肝肾脑等