高级病理学王鹏幻灯片.pptVIP

高级病理学 高级病理学 姓名：王鹏 研究方向：分子病毒与免疫学 * * 高级病理学 猪圆环病毒-很小很强大 * 高级病理学 * Contents 1.The virus and the disease 2.The viral genome 3.The viral proteins 4.Replication of PCV 5.Virus import * 高级病理学 * 1. The virus and the disease Porcine circovirus (PCV) was originally identi?ed as a con- taminant of porcine kidney cell cultures (PK-15) . The PCV virion is icosahedral(二十面体）, nonenveloped, and 17nm in diameter（直径）. The genome of PCV is a single-stranded circular DNA of about 1.76 kb. PCV is classi?ed in the genus Circovirus of the Circoviridae family, which consists of other animal circoviruses such as psittacine（鹦鹉） beak-feather disease virus, goose circovirus, canary （金丝）circovirus, and pigeon circovirus(PiCV). * 高级病理学 * Two genotypes of PCV have been recognized The PK15 cell-derived PCV has been considered to be non-pathogenic to pigs and is designated PCV type 1(PCV1). PCV type 2 (PCV2) is now accepted as the major infectious agent involved in postweaning multisystemic wasting syndrome (PMWS) , a new emerging swine disease worldwide since its occurrence in Canada in 1991. * 高级病理学 * Postweaning Multisystemic Wasting Syndrome (PMWS) Infection with porcine circovirus type 2 (PCV2), but not PCV1, has been associated with postweaning multisystemic wasting syndrome (PMWS) in young weaned pigs. Usually PMWS appears in pigs aged 5 to 18 weeks, and affected pigs show wasting, respiratory distress, enlarged lymph nodes and, occasionally, jaundice and diarrhea . Gross lesions in affected pigs consist of generalized lymph adenopathy in combination with interstitial pneumonia, hepatitis, renomegaly, splenomegaly, and intestinal wall edema Other syndrome 1.porcine dermatitis and nephropathy syndrome,PDNS 2.porcine respiratory disease complex, PRDC 3.proliferative and necrotising pneumonia, PNP 4.congenital tremor AII, CT-AII * * 高级病理学 * 高级病理学 * 2. The viral genome PCVs contain a circular ssDNA molecule with a size of 1759in case of PCV1 and 1768 for PCV2. They are the smallest m