Investigator Portal药物研发数据库讲座课件.ppt

Investigator Portal有效沟通研究信息，加速新药研发进程 Prous Science – since 1958 Investigator Portal – 数据库主要内容 Investigator Portal – 专业的数据编辑人员 来自不同专业领域，多数拥有博士学位，受过良好的专业科学研究训练： Clinical researchers Chemists Pharmacists Epidemiologists Biostatisticians Geneticists Bioengineers Biologists Data managers Pharmacologists 药物研发行业周期图 Alzheimer’s Drugs - Overview 药物研发行业周期图 Experimental Pharmacology The Experimental Pharmacology Knowledge Area offers a display format, called Structure Activity, that allows for comparison of chemical structures and biological activity with citations of specific values. Abbreviations used for parameters in Experimental Pharmacology include: ? CC - Cytotoxicity ? EC - Effective Concentration ? ED - Effective Dose ? IC - Inhibitory Concentration ? Kb - Equilibrium Dissociation Constant for an antagonist ? Kd - Equilibrium Dissociation Constant ? Ki - Affinity/Inhibitory Constant ? Ki(h) - Affinity/Inhibitory Constant (high affinity component) ? Ki(l) - Affinity/Inhibitory Constant (low affinity component) ? LD - Lethal Dose ? MBC - Minimum bactericidal concentration ? MCC - Minimum cytotoxic concentration ? MEC - Minimum effective concentration ? MED - Minimum effective dose ? MFC - Minimum Fungicidal Concentration ? MIC - Minimum Inhibitory Concentration ? MID - Maximum Inactive Dose ? MLD - Minimum Lethal Dose ? MPC - Mutation Prevention Concentration ? MTD - Minimum Tolerated Dose ? MUD - Minimum Ulcerogenic Dose ? NTD - Non-toxic Dose ? UD - Ulcerogenic Dose ? pA-2 - Antagonism Constant Pharmacokinetics Retrieve PK data on a specific drug or drugs. Abbreviations used for parameters in the Pharmacokinetics Knowledge Area: ? AUC (A-B) - Area under curve for a given interval from time A to time B in hours ? BR (A-B) - Biliary recovery between time A and time B (in hours). ? Cl – Clearance; the rate of elimination by all routes ( or by specified route(s) and mechanism(s) of elimination, as indicated by a letter in parenthesis ? Cl(B) - Biliary cle