SEIZURES新生儿惊厥（PPT55）课件.ppt

Major Etiologies of Neonatal Seizures in Relation to Time of Seizure Onset and Relative Frequency TIME OF ONSET* RELATIVE FREQUENCY? 0-3 DAYS 3DAYS PREMATURE FULL TERM Hypoxic-ischemic + +++ +++ encephalopathy Intracranial + + ++ + hemorrhage? Intracranial infection + + ++ ++ Developmental + + ++ ++ defects Hypoglycemia + + + Hypocalcaemia + + + + Other metabolic + + Epileptic syndromes + + + Inborn Errors of Metabolism Associated With Neonatal Seizures Conditions That Have a Specific Treatment Pyridoxine (B6) dependency Folinic acid-responsive seizures Glucose transporter defect Creatine deficiency Other Conditions Nonketotic hyperglycinemia Sulfite oxidase deficiency Molybdenum cofactor deficiency (combined deficiency) Carbohydrate-deficient glycoprotein disorder Lactic acid disorders Mitochondrial disorders Maple syrup urine disease Isovaleric acidemia (sweaty feet, cheesy odor) Inborn Errors of Metabolism Associated With Neonatal Seizures Other conditions Isovaleric acidemia (sweaty feet, cheesy odor) 3-methylcrotonyl-CoA carbosylase deficiency Propionic acidemia Mevalonic aciduria Urea cycle defects Hyperornithemia-Hyperammonemia-Homocitrullinuria (HHH) syndrome Neonatal glutaric aciduria type ll Biotin deficiencies, holocarboxylase synthetase deficiency Fructose 1,6-diphosphatase deficiency Hereditary Fructose intolerance Menkes disease (trichopolio