Vitamin B6 and B12 Intakes in Relation to Risk of 叶酸维生素B6和B12摄入量关系风险课件.ppt

Folate, Vitamin B6, and B12 Intakes in Relation to Risk of Stroke Among Men  Ka He, MD;Anwar DMD; Eric B;. Rimm, ScD;Bernard A. Rosner, PhD; Meir J. Stempfer, MD;Walter C. Willett, MD; Alberto Ascherio, MDStroke. 2004;35:169-174Folate Intake and Risk of Stroke Among Wemen Wael K. Al-Delaimy, MD, PhD;Kathryn M. Rrxrode, MD, MPH; Frank B. HU, MD, PhD; Christine M. Albert, MD, MPH; Meir J. Stampfer, MD, DrPH;Walter C. Willett, MD, DrPH; John E. Manson, MD, DrTHStroke. 2004;35:1259-1263 翁履珍 Folate (Folic acid) Water Soluble Functions  i. Red blood cell formation ii. New cell division iii. Protein metabolism Deficiencies Anemia, diarrhea, depression, heartburn Toxicity Insomnia, irritability, diarrhea, may mask B12 deficiency Recommended Intakes (RDA): 400 μg/day for adults Food Sources Green leafy vegetables, liver, legumes, seeds, and enriched breads, cereals, rice, and pasta. Homocysteine CVD Homocysteine level stroke (Brattstrom, et al.1992; ) Elevated homocysteine level Genetic defects (Brattstrom, et al.1998) Low intake of folate, vitamin B6 vitamin B12 (Verhoef, et al.1996) Folate metabolism Study 1 Examining the relationship between prospectively intakes of folate and vitamin B6 and vitamin B12 and incidence of ischemic and hemorrhagic stroke in a large cohort of US men with an average 14 years of follow-up. Dietary Assessment Assessed in 1986, 1990, and 1994 Semiquantitative food frequency questionnaires (FFQ) Commenly used portion size Never or1/month to ≧6/day Nutrition intakes = average nutrient content × frequency Harvard University food composition Database Outcome Assessment Statistical Analyses Divided into quintiles according to intakes of B vitamins Incident rate = Case number ÷ person time (follow-up in each quintile) Relative Risk (RR) = The incident of stroke in a particular quintile compare with