e-钙粘附素和α-连接素与乳腺癌相关性研究论文华北煤炭医学院.docVIP

华北煤炭医学院硕士学位论文  2  E-Cad 表达状况与淋巴结转移  远处转移相关  P0.05  而与年龄  术前月经情况  乳腺癌组织学类型 肿瘤大小无相关性  -Cat 表达状况与淋巴结转移相关 P0.05  而与年龄  术前月经情况  乳腺癌组织学类型  肿瘤大小  远处转移无相关性  3  多因素 COX 回归显示  淋巴结转移和 E-Cad 是乳腺癌患者预后的独立预测因子  淋  巴结阳性患者手术后死亡的相对危险度是淋巴结阴性患者的 3.284 倍  E-Cad 表达阳  性患者手术后死亡的相对危险度是 E-Cad 表达阴性患者的 0.325 倍  若将 E-Cad 及  -Cat 作为一个复合因素 结论  则 E-Cad-  -Cat 也可以用来预测乳腺癌患者的预后  1  E-Cad 和 腺瘤 低  -Cat 在乳腺癌癌组织表达阳性率较乳腺良性组织 乳腺增生症 及乳腺纤维  2  E-Cad 表达状况与乳腺癌腋淋巴结转移 P0.05  远处转移(P0.05)密切相关  -Cat  表达强度与乳腺癌腋淋巴结转移  P0.05  密切相关  3  E-Cad 的表达状况 淋巴结转移情况可以作为乳腺癌预后的独立预测因子 达阴性 淋巴结转移阳性的乳腺癌患者预后不良  E-Cad 表  4  E-Cad-  -Cat 表达状况可以作为乳腺癌预后的预测因子  E-Cad 和  -Cat 中一个表达  阴性或同时表达阴性的乳腺癌患者预后不良 关键词  乳腺癌  E-Cad  -Cat  预后  第 2页 华北煤炭医学院硕士学位论文 Related study on the expression of E-Cad and -Cat in breast cancer Abstract Objective  In this study ,we studied the expression pattern of E-Cad and  -Cat to evaluate the  relations between the expression pattern of E-Cad or  -Cat and the clinicopathologic characters  of breast cancer ,to evaluate the clinical values of E-Cad and  -Cat in predicting the  invasive ,metastatic potential and prognosis of breast cancer, and to provide useful molecular biological indicators for comprehensive therapies to breast cancer. Materials and Methods  1  146 patients were selected who underwent surgical resection for breast carcinoma  at our  hospital form January 1992 to June 1996.A retrospective study was conducted on the 120 people whose survival data were available .  2  The expression of E-Cad and  -Cat was determined by means of immunohistochemistry in  the cancer specimens of the 77 random samples selected from the 120 patients .A control group includes 15 speciments of breast fibroadenoma and breast proliferation.  3  Multivariate analyses were performed by using the COX proportional hazards model to analyze the following conventional prognostic factors in relation to the length of disease-specific survival: age, histological type of tumor,