Recent insights from animal myopia research从动物的近视的研究的新见解.pptVIP

Recent insights from animal myopia research Christine Wildsoet University of California - Berkeley Animal models for myopia - Common animals paradigms Important questions Do similar mechanisms underlie lens-induced- form deprivation-myopia? How do eyes distinguish between myopic hyperopic defocus? What signals pass from the retina to the sclera? Can animals be used to model the refractive effects of eye diseases The lens defocus models Form Deprivation-Myopia Lens-induced Myopia are different Refractive compensation to imposed defocus (active emmetropization) in chicks Important questions Do similar mechanisms underlie lens-induced- form deprivation-myopia? How do eyes distinguish between myopic hyperopic defocus? What signals pass from the retina to the sclera? Can animals be used to model the refractive effects of eye diseases Light at night inhibits lens-induced but not form deprivation myopia Important questions Do similar mechanisms underlie lens-induced- form deprivation-myopia? How do eyes distinguish between myopic hyperopic defocus? What signals pass from the retina to the sclera? Can animals be used to model the refractive effects of eye diseases? Decoding defocus Stimuli for decoding defocus High spatial frequencies seem to be important for decoding myopic defocus Abnormal growth can increase monochromatic aberrations Eye growth is chromatically tuned High frequency A-scan ultrasonography Sign but not power of lens used to decode defocus Cues for decoding defocus Myopic example High spatial frequencies moderate to high contrast important for decoding myopic defocus Monochromatic aberrations  eye growth in chick Induced myopia increases aberrations in chicks Important questions Do similar mechanisms underlie lens-induced- form deprivation-myopia? How do eyes distinguish between myopic hyperopic defocus? What signals pass from the retina to the sclera? Can animals be used to model the refractive effects of eye diseases? How much of e