COMPLEENT Stritch School of Medicine补体Stritch医学.ppt

Here is what Step 1 covers- did we get them all? Production/function granulocyte, NK cells and macrophages/DC Production/function of T cells, TCR, cytokines/chemokines Production/function of B cells and PC, Ig structure, classes, molecular basis for specificity, receptors Antigenicity/immunogenicity, host defenses(read Innate I), primary/secondary responses, passive transfer of immunity(all ways) In vitro complement, other diagnostic tests and antigen antibody reactions Mediators, complement, aa, histamine, NO and cytokines MHC structure and function, RBC antigens. Transplantation Vaccines, protective immunity, tumor immunity Disease states like ID, HIV and pharmacological immunosuppression INNATE IMMUNITY NOT ANTIGEN SPECIFIC HAS NO MEMORY MEDIATED BY NEUTROPHILS MACROPHAGES/MONOCYTES NATURAL KILLER CELLS EOSINOPHILS BASOPHILS/MAST CELLS MANNOSE BINDING PROTEIN AND COMPLEMENT PROSTAGLANDIN KININ SYSTEMS INDISCRIMINATE DESTRUCTION PRO-INFLAMMATORY CYTOKINES ADAPTIVE IMMUNITY ANTIGEN SPECIFIC CLONAL EXPANSION AMPLIFIES AN IMMUNE RESPONSE AFTER A SPECIFIC RECEPTOR INTERACTION INTEGRATES THE INNATE RESPONSE INTO THE REACTION MEMORY OF THE ENCOUNTER KNOW THESE DIFFERENCES ANATOMY OF THE IMMUNE SYSTEM B-CELL DEVELOPMENT ANTIBODY STRUCTURE ANTIBODY FUNCTIONS ANTIBODY FUNCTIONS COMPLEMENT FLUID PHASE AMPLIFIER OF INNATE AND ANTIBODY MEDIATED RESPONSES THREE ARMS ALTERNATE-BACTERIAL CELL WALLS MANNOSE BINDING-BACTERIAL CELL WALLS and MBP DIRECT(CLASSIC)-SPECIFIC Ag/Ab REACTIONS COMPLEMENT ENZYME ACTIVATED CASCADE WITH GENERATION OF INFLAMMATORY AND REGULATORY FRAGMENTS ACTIVATES INFLAMMATORY CELLS BY SPECIFIC RECEPTOR INTERACTIONS HAS IMPORTANT IMMUNOREGULATORY AND IMMUNE COMPLEX DISPOSAL ROLES Measured by serum C3 and C4, total hemolysis and individual components COMPLEMENT-RELATED DISEASES Rare C1esterase deficiency with angioneurotic edema- Deficiencies in the direct sequence associated with IC diseases like SLE Homozygous C3 is lethal Deficiencies in the alternate