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Resonance Imaging in Ischaemic Heart Disease (ASM 2011)磁共振成像在缺血性心脏病(ASM 2011)课件
* * * * * * * * * * * * * * * * * * * * * * * * * * * * Contraindications of Adenosine Acute Myocardial infarction within few days Asthma Second- or third-degree atrio-ventricular block Sick sinus syndrome Symptomatic bradycardia Patient Preparation for Adenosine Stress MRI Exam. Refrain from caffeinated food and drink for 24 hours Such as coffee, tea, coke and chocolate Adenosine antagonist Interfere with the ability of Adenosine to dilate arteries False negative examination result Adenosine Stress Cardiac MRI Exam. Adenosine at 140?g/kg/min intravenously for 4 mins Gadolinium-DTPA (0.05 mmol/kg) is rapidly infused (4ml/sec) First-pass imaging is performed using gradient echo pulse sequence on multiple short axis slices (basal, middle, and apex) of the left ventricle during a breath hold Adenosine Stress Cardiac MRI Exam. Normal myocardium shows a “blush” of bright signal throughout the cardiac cycle Ischaemic or infarcted myocardium will show a persistent dark signal, either subendocardial or transmural in location The perfusion defect shall follow the supply territory of the coronary arteries Myocardial Viability Differentiation between viable and non-viable myocardium is important Transmural extent Viable myocardium may benefit from revascularization and resume normal cardiac function Function cannot be restored to nonviable tissue Myocardial Infarction Post-gadolinium myocardial delay enhancement technique Areas of infarct or scar have increased volume of distribution of gadolinium as compared to normal myocardium There is more efficient egress of gadolinium from normal myocardium compared to infarcted tissue Hyperenhancement of infarcted myocardium 10-20mins after contrast administration Ischaemia vs Infarction Ischaemic and infarcted myocardium can be differentiated by first-pass myocardial perfusion and myocardial delay enhancement techniques Ischaemic but viable myocardium Non-viable myocardium Rest perfusion Normal signal Signal loss Stre
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