2010留学生流行性乙型脑炎课件.pptVIP

Epidemic encephalitis B Department of Infectious Diseases of the Second Affiliated Hospital of Nanchang University SUN Shui-lin Definition Epidemic encephalitis B Abbreviation : Japanese encephalitis , It a acute inflammatory diseases that Caused by Japanese encephalitis virus in brain parenchymal lesions Clinical features Acute onset Protruding heat Disturbance of consciousness Twitch Pathological reflex and meningeal irritation Severe cases may have respiratory failure Etiology Japanese encephalitis virus is an arbovirus group B of the Flaviviridae, spherical, about 40 ~ 50nm, the core is a single strand RNA, outside to membrane proteins and outer membrane protein ★ Virus resistance to weak, except the low temperature and dry Of human infection with the virus can produce complement binding antibody, neutralizing antibody and serum inhibition antibody Electron micrograph of JE virus particles in an infected neuron Epidemiology Source of infection: humans and animals (livestock, poultry), especially the piglets are the main source of infection, humans were not an important source of infection Transmission: the mosquito is the major media, no disease after infection, the virus can be carried by the mosquito during wintering and passaged by eggs Susceptible: generally susceptible, covert infection is the major spectrum, incidence: 1:1000 ~ 2000 ,patients were more common in under the age of 10 (2 to 6 years) children ,lasting immunity Epidemiology Epidemiological characteristics: there are strict seasonal, concentrated in 7,8,9 months (80% ~ 90%), and strong regional (Asia-based) Pathogenesis Mosquitoes (with virus) ? Bites ? The virus enters the human body ?The breeding of mononuclear phagocytes ? Released into the blood ? Immunocompetent ? Transient viremia ? pathogen removal Immunity lower? through