肾上腺素联合甲氧明在心肺复苏中应用研究.docVIP

肾上腺素联合甲氧明在心肺复苏中应用研究 　　【摘要】目的 通过窒息法制备家兔心搏骤停模型，探索肾上腺素联合甲氧明在心肺复苏过程中的应用。方法 将27只家兔随机（随机数字法）分为甲氧明组、肾上腺素组、联合用药组，每组9只。建立窒息型家兔心搏骤停模型后，复苏时三组家兔分别予甲氧明、肾上腺素、联合用药。记录家兔窒息前与复苏成功后15、30、60、120 min各时间点的心率、平均动脉压和心电图的变化；比较实验各组家兔自主循环恢复率和2 h存活率。复苏成功后2 h取心肌组织进行光镜及电镜检查。结果 甲氧明组、肾上腺素组、联合用药组三组分别有1只、6只、5只家兔复苏成功。自主循环恢复后家兔心率及平均动脉压值均较窒息前有明显下降（P 　　【关键词】窒息；心搏骤停；心肺复苏；肾上腺素；甲氧明 　　Study of the effects of epinephrine combined with methoxamedrine on cardiopulmonary resuscitation HU Nian-dan， LI Wen-qiang， WEI Jie， DU Xian-jin， SU Wei-wei. Department of Emergency Medicine， Renmin Hospital of Wuhan University， Wuhan 430060， China 　　Corresponding author： LI Wen-qiang， Email： wenqiang67@ 　　【Abstract】Objective To investigate the effect of epinephrine combined with methoxamedrine on rate of successful cardiopulmonary resuscitation （CPR） in rabbit model of sudden cardiac arrest by the method of clamping the trachea to asphyxia.Methods Twenty-seven rabbits were randomly （random number）divided into methoxamedrine group， epinephrine group and epinephrine combined with methoxamedrine group. After the modeling， rabbits in the three groups were treated methoxamedrine， epinephrine， and epinephrine combined with methoxamedrine respectively by intravenous injection during CPR. The change of heart rate （HR）， mean arterial pressure （MAP） and electrocardiogram （ECG）， restoration of spontaneous circulation （ROSC） and mortality within 2 hours of each experimental group were recorded before suffocation and 15 min， 30 min， 60 min， 120 min after the success of the resuscitation. The pathological changes of myocardium were observed under optical and electronic microscope. Results The number of ROSC rabbits in methoxamedrine group， epinephrine group and epinephrine combined with methoxamedrine group were 1， 6， 5 respectively. The heart rate and mean arterial pressure of the rabbits after ROSC were lowered compared with those before suffocation significantly （P 　　【Key words】Asphyxia； Cardiac arrest； Cardiopulmonary resuscitat