fMRI Activation in a Visual-Perception Task Network of ：fMRI激活在视觉感知任务网络.pptVIP

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fMRI Activation in a Visual-Perception Task Network of ：fMRI激活在视觉感知任务网络.ppt

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fMRI Activation in a Visual-Perception Task Network of ：fMRI激活在视觉感知任务网络

fMRI Activation in a Visual-Perception Task: Network of Areas Detected Using the General Linear Model and Independent Components Analysis Calhoun, Adali, McGinty, Pekar, Watson, Pearlson (2001). Geneviève Desmarais - November 5, 2002 MVPT-R Motor-free Visual Perception Task (Revised) Probes: spatial relationships visual discrimination figure-ground perception visual closure etc... Basic Paradigm Participants 2 females, 8 males mean age 27 screened with physical and neurological exam no Axis 1 disorders (clinical) good visual acuity without correction Imaging Parameters Anatomic Scan T-1 weighted TR = 500 msec TE = 30 msec slice thickness = 5 mm gap = 0.5 mm 18 slices through entire brain Functional Scan single-shot echo-planar TR = 1 s TE = 39 msec 5 min = 300 scans 10 dummy scans at beginning Data Analysis - Preprocessing(fudging?) Corrected for timing differences Motion corrected Spatially smoothed Normalized to Talairach space Data AnalysisGeneral Linear Model 1. Fixed-effect group analysis stimulus function times when figures were presented to the participants Filters: High-pass Low pass trends verified in each individual data set 2. Random effect analysis on individual data Data AnalysisIndependent Component Analysis Decomposes data into signals that are maximally independent individual preprocessed data arranged into 2D matrix of space and time 20 components estimated, grouped into: motor, visual, cerebellar, frontoparietal, orbitofrontal, and basal ganglia Data AnalysisIndependent Component Analysis Components normalized Components within each area averaged across participants Each group image converted to Z scores threshold = 2.5 Results 85% average correct response range 67 - 100 (…) Incorrect and correct responses grouped together ActivationGLM analysis ActivationICA analysis Discussion Expected activation in: large network of areas involved in visual and spatial perception all primary visual areas and many visual association areas Event-aver