Inhibition - jonesLab抑制- joneslab.pptVIP

* Retrieval practice led subjects to forget related items on a delayed test * Selective memory retrieval--Likely to be action of inhibitory control process acting to override unwanted retrieval of competitors in memory * Selective memory retrieval--Likely to be action of inhibitory control process acting to override unwanted retrieval of competitors in memory * Think/no think paradigm: Were told to not think of the corresponding word when they saw the cued word * Stroop task example Inhibition Chris Jung Department of Integrative Physiology 09/23/08 Outline Prefrontal Neurons Coding Suppression of Specific Saccades Hasegawa RP, Peterson BW, and Goldberg ME The role of inhibitory control in forgetting unwanted memories: A consideration of three methods. Anderson MC In Opposition of Inhibition MacLeod CM, Dodd MD, Sheard ED, Wilson DE, and Bibi U Prefrontal Neurons Coding Suppression of Specific Saccades Hasegawa, R.P., Peterson, B.W., Goldberg, M.E. (2004). Neuron, 43, 415-425. Introduction Methods Results Conclusions Introduction Monkey and humans that do not avoid looking at something can be seen as socially offensive, unacceptable. Introduction Eye fixation is an active process Two mechanisms have been proposed: An inhibition of the saccadic system by the fixation system When fixation occurs, the threshold for evoking saccades increases by electrical stimulation from the frontal eye field (FEF) and the superior colliculus, which are apart of the fixation system Some neurons of the FEF are activated if a stimulus is present to cancel the saccade such as in a “go/no go task” Methods Caudal part of dorsolateral prefrontal cortex Match/Non Match Task Figure 1 Look neurons Enhanced response if the monkey knew a priori of a saccade target 10% of samples Sample Period: 3 Different Responses Don’t look neurons Enhanced response if the monkey knew a priori of a non-saccade target, or to avoid looking at the original stimulus 10% of sample Sample Period: