肺癌筛查对新发结节的研究概要1.pptx

Occurrence and lung cancer probability of new solid nodules at incidence screening with low-dose CT: analysis of data from the randomised, controlled NELSON trial 2 of 39 Lung cancer is a leading cause of death worldwide. US guidelines now recommend lung cancer screening with low-dose CT for high-risk individuals. So far, most research has focused on lung nodules detected during baseline screening. Introduction 3 of 39 Introduction Reports of new nodules after baseline screening have been scarce and are inconsistent because of differences in definitions used. Because these nodules developed within a short time-interval, Lung cancers found in incidence screening rounds tend to be more aggressive than those detected at baseline. 4 of 39 Up to now, no study has focused on new solid nodules found during lung cancer screening. We aimed to identify the occurrence of new solid nodules and their probability of being lung cancer at incidence screening rounds in the Dutch-Belgian Randomized Lung Cancer Screening Trial (NELSON). Introduction 5 of 39 Dutch Belgian randomised lung cancer screening trial (NELSON) 6 of 39 Organisation： Erasmus Medical Centre (Netherlands) Participating centres: University Medical Centre Groningen, University Medical Centre Utrecht, Kennemer Gasthuis Haarlem (the Netherlands), and University Hospital Leuven (Belgium). Dutch Belgian randomised lung cancer screening trial (NELSON) 7 of 39 Dutch Belgian randomised lung cancer screening trial (NELSON) 8 of 39 Participant inclusion criteria 1. Born between 1928 and 1956（50-75years）2. Smoked:2.1. More than 15 cigarettes per day for more than 25 years, or2.2. More than 10 cigarettes per day for more than 30 years3. Current or former smokers who quit smoking less than or equal to 10 years ago Participant exclusion criteria 1. Moderate or bad self-reported health who were unable to climb two flights of stairs2. Body weight greater than or equal to 140 kg3. Current or past renal