BLOOD－hjzjames.ppt

* * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * General Process * Plasminogen Activator Plasminogen Plasmin Fibrin and Fibrinogen Fibrin Degradation Products (FDP) 纤溶酶原 Activation of Plasminogen to Form Plasmin – Plasminogen Activator There are two types of plasminogen activator Vessel activator. Some clotting factors in the intrinsic pathway, such as XIIa, XIa, prekallikrein , HMW kininogen, IIa (thrombin) et al. Tissue activator. Released by the injured tissue and endothelium tissue-type plasminogen activator (t-PA) urokinase synthesized by the kidney * * Degradation of the fibrin Plasmin is a most powerful proteolytic enzyme. digest the fibrin, fibrinogen, Factor V, VIII, prothrombin and Factor XII. whenever plasmin is formed in a blood clot, it can cause lysis of the clot and destruction of many of the clotting factors, sometimes even causing hypocoaguliability of the blood * Degradation of the fibrin Human t-PA is produced by recombinant DNA technique and available for clinical use. lyses clots in the coronary arteries if given to patients soon after the onset of myocardial infarction. Streptokinase and urokinase are also fibrinolytic enzymes used in the treatment of early myocardial infarction * Significance of the Fibrinolysis allows slow clearing (over a period of several days) of extraneous clotted blood in the tissue and sometimes allows reopening of clotted vessels. to remove minute clots from the millions of tiny peripheral vessels that eventually would become occluded were there no way to clean them. * Significance of the Fibrinolysis plays an important role in maintaining the fluidity of the blood or normal capillary flow, which benefits the repairing and healing of the damaged tissues. * *  Ⅳ.The Role of Platelets in Hemostasis Formation of the Platelet Plug Participation in the Blood Coagu