upa upar及mmp-2在子宫颈鳞癌组织表达及临床意义-expression and clinical significance of upa upar and mmp - 2 in cervical squamous cell carcinoma.docx

of positive expression of uPA was significantly higher than that in those without the conditions mentioned above(P0.05). The expression of uPAR in SCC group correlated with histological grading and pelvic lymph node metastasis (P0.05). Inthe cases with histological grading ≥Ⅱ and pelvic lymph node metastasis, the rate ofpositive expression of uPAR was significantly higher than that in those without the conditions mentioned above(P0.05). The expression of MMP-2 in SCC group correlated with FIGO staging and pelvic lymph node metastasis (P0.05). In the cases with FIGO stagingⅡand pelvic lymph node metastasis, the rate of positive expression of MMP-2 was significantly higher than that in those without the conditions mentioned above(P0.05).In the cases with uPA, uPAR and MMP-2 all being positive expressions in SCC group, the PI, MVD and prevalences of pelvic lymph node metastasis were statistically higher than those in the cases with uPA, uPAR and MMP-2 all being negative, respectivey. The expression of uPA in SCC group was significantly positivecorrelated with uPAR (r=0.617，P=0.000) and MMP-2 (r=0.582，P=0.000). Theexpression of uPAR in SCC group was significantly positive correlated with MMP-2 (r=0.617，P=0.000).ConclusionsOver coexpression of uPA, uPAR and MMP-2 in SCC group may result in rapid tumor angiogenesis, proliferation of cancer cells and great increase of cancer invasion and metastasis.Keywordscervical neoplasm; urokinase plasminogen activator(uPA); urokinase plasminogen activator receptor(uPAR); matrix metalloproteinase-2(MMP-2); immunohistochemistry缩略词表尿激酶型纤溶酶原激活物（urokinase-type plasminogen activator，uPA) 尿激酶纤溶酶原激活剂受体(urokinase-type plasminogen activator receptor，uPAR) 金属基质蛋白酶-2(matrix metalloproteinase 2，MMP-2) 血管内皮生长因子(vascular endothelial growth factor , VEGF) 细胞外基质(extracellular matrix，ECM)基底膜(basement membrane，BM)正常子宫颈上皮 (normal cervical epithelium，NCE) 宫颈上皮内瘤样病变 （cervical intraepithelial neoplasia，CIN） 鳞状细胞癌（squamouseellcancer，SCC） 糖基化磷酸肌醇(Glycosyl p