苯乙烯分散共聚合的基础分析及微球的应用分析-basic analysis of styrene dispersion copolymerization and application analysis of microspheres.docx

成沸石涂层并进而获得空心纤维的必要条件，电泳时间和电泳液浓度也对沸石沉积有一定影响。阜●为了拓展功能化微球在生物医学方面的用途，对分散共聚合制备的羧基微球，将寡聚核苷酸(ODN)化学键合于其表面，发现反应体系的pH值、核苷酸用量及温 度等条件对寡聚核苷酸固定效率有一定的影响。战们尝试利用微球固载的寡聚核苷 酸探针和固定在玻璃片上的特异互补HCV序列杂交，初步确定了光学显微镜问接 检测DNA杂交的可能性。吱AbstractMicron—size monodisperse polymer particles have a wide variety of scientific and technological applications，such as standard calibration，biomedical and clinical diagnosis， HPLC fillers，catalyst carriers，coatings and ink additives，information storage materials and colloidal crystals．Dispersion polymerization is a very attractive method to prepare micron—size monodisperse polymer particles(1-159m)due to the inherent simplicity ofits single—step process．Preparation of micron—size monodisperse homopolymer particles has been extensively studied．However，few studies on unseeded batch dispersion copolymerization have been reported．The reason is that dispersion copolymerization is highly sensitive to numerous reaction parameters involved in the process．Here dispersion copolymerization of styrene(st)and other seven vinyl monomers was carried out in polar solvents．Among those comonomers are water-soluble monomers such as acrylamide(Am)and acrylic acid，hydrophilic monomers such as glycidylmethacrylate (GMA)， methyl methacrylate， ethyl methaerylate， and 3-(trimethoxysilyl)propyl methacrylate，and hydrophobic monomer such aS N-vinyl carbazole mvc)．The particle size first decreased and then increased with increasing the fraction of acrylamide in the monomer feed，and at higher fraction of such water—soluble comonomer only gel—like polymer was obtained．The particle size also increased with the increase of the content of the hydrophilic comonomers in the monomer mixture，and the copolymer molecular weight decreased meanwhile．When the amount of the hydrophobiccomonomer in the monomer mixture changed，the particle size，size distribution andmolecular weight were hardly affected．The effects of various polymerization parameters on the particle size and size distribution were