不同剂量布地奈德对哮喘大鼠肺组织bcl-2 bax和p-erk12表达影响的实验研究-effects of different doses of budesonide on bcl - 2 bax and p - er k12 expression in lung tissue of asthmatic rats.docxVIP

ABSTRACTObjectives: 1. To study the expression and correlation of apoptosis-related gene Bcl-2 and Bax and phosphorylated extracellular signal-regulated kinase 1/2 (p-ERK1/2),.2. To investigate the pathological changes of asthmatic rat lung tissue, the expression of Bcl-2 and Bax and p-ERK1/2, and the effection of Bcl-2/Bax with different doses of budesonide intervention.Methods: 1.In this experiment, 5~6 weeks old SD rats as the experimental object，rats were randomly divided into normal control group(control group), Asthma model group (asthma group),budesonide daily intervention group (interv