肱踝脉搏波传导速度 同型半胱氨酸与冠心病相关性分析-correlation between homocysteine and coronary heart disease in brachial-ankle pulse wave velocity.docxVIP

肱踝脉搏波传导速度、同型半胱氨酸与冠心病相关性研究肱踝脉搏波传导速度、同型半胱氨酸与冠心病相关性研究ⅡⅡAbstractObject:1、To explore the predictive values of Brachial-ankle pulse wave velocity（baPWV）、serum homocysteine（Hcy）in diagnosis of coronary heart disease（CHD）and severity of coronary stenosis；2、 To explore the relationship between Brachial-ankle pulse wave velocity（baPWV）,serum homocysteine（Hcy） and left ventricular function in patients with Coronary artery disease（CAD）.Methods：1、The patients having coronary angiography (CAG, n=196) were divided into the CHD group (n=131) and non-CHD group (n=65) according to the outcomes of CAG. The CHD group was divided again into three sub-groups: mild group, moderate group and severe group according to the severity of coronary stenosis (SYNTAX grading).The changes of baPWV were detected by using the measure system of PWV in all patients before CAG, serum Hcy levers were measured by the fluorescencepolarization immunoassay (FPIA)；2、According to the outcomes of CAG,142 patients with CAD wereenrolled in the study, EF、E、A、Ea were measured by echocardiography,calculate E/Ea ratio.The patients were divided into two groups:E/Ea≥15 group and E/Ea＜15 group.Results: 1、The differences of baPWV and Hcy were statistically significant between the CHD group and non-CHD group(P0.01);Severe group showed higher Hcy than the moderate group and mild group(P0.05);In three sub-groups,the difference of baPWV was statistically significant among mild group,moderate group and severe group(P0.05);There was a positive correlation between baPWV、Hcy andSYNTAX score.2、The differences of baPWV and Hcy were statistically significant between the E/Ea≥15 group and E/Ea＜15 group (P0.05);There was a positive correlation between baPWV、Hcy and E/Ea.Conclusion:1、 baPWV and Hcy have predictive values in diagnosis of coronary heart disease.2、baPWV and Hcy have predictive values in diagnosis of diastolic cardiac dysfunction in CAD patients.Key words: pulse wave velocity;homocysteine;SYNTAX sco