Hypothermia-inducedneuroprotectionanditsabilitytoattenuate低温诱导的神经保护作用及其能力减弱.pptVIP

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Hypothermia-inducedneuroprotectionanditsabilitytoattenuate低温诱导的神经保护作用及其能力减弱.ppt

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Hypothermia-inducedneuroprotectionanditsabilitytoattenuate低温诱导的神经保护作用及其能力减弱

Hypothermia-induced neuroprotection and its ability to attenuate the down-regulation of GluR2 and GluR1 By Alina Segura BIO 475 Dr. Peter Lin Spring Semester Contents Overview of the CNS Glutamate Receptor AMPA Receptor Hypothermia Survival of hippocampal CA1 neurons Down-regulation of AMPA receptor GluR2 subunit Future Research Conclusion Overview of Central Nervous System (CNS) Brain + Spinal Cord Brain consists of: forebrain, midbrain, hindbrain Forebrain: Telencephalon is its surrounding structure Plays major roles in the sensory perception, learning, memory, and conscience behavior Consists of the Limbic System The Limbic System Responsible for the psychological drives, instincts, and emotions The Hippocampus Transfer of short-term memory to long-term memory Defined structure Visible layer of pyramidal cells CA1 CA3 Dentate Gyrus The Hippocampus Glutamate Receptor Main component of proteins Present in many tissues Produced in the body Plays essential role in human metabolism Major excitatory neurotransmitter in CNS Receptor plays a vital role in the mediation of excitatory synaptic transmission Glutamate Receptor Consists 4 or 5 subunits that are subdivided into these receptors: NMDA AMPA Kainate All ionotropic glutamate receptors share common basic structure Ionotropic Glutamate Receptors Synaptic Transmission Synthesis of glutamate (GLU) from glutamine Transport and storage Release of GLU by exocytosis Binding of GLU to antagonist receptors Binding to presynaptic receptors Reuptake Degradation AMPA Receptor Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid Composed of GluR2-4 Channels are impermeable to calcium ions However, the calcium permeability of the GluR2 subunit is determined by the post-transcriptional editing of the GluR2 mRNA AMPA Receptor Change in single amino acid in the TM2 region from glutamine (Q) to arginine (R) GluR2 (Q) is calcium permeable Ischemia Condition in which tissues and organs suffer inadequate blood flow in part