CARDIACTOXICOLOGY-TheUniversityofNorthCarolinaat心脏毒理学-北卡罗来那大学.pptVIP

下载本文档

6
0
约1.31万字
约 58页
2018-06-30 发布于浙江
举报
版权申诉

CARDIACTOXICOLOGY-TheUniversityofNorthCarolinaat心脏毒理学-北卡罗来那大学.ppt

1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

CARDIACTOXICOLOGY-TheUniversityofNorthCarolinaat心脏毒理学-北卡罗来那大学

CARDIAC TOXICOLOGY James Swenberg University of North Carolina Basic Myocardial Structure Cardiac muscle is striated, BUT : single nucleus under autonomic control all cardiac cells contract together (skeletal - selective recruitment of motor units) high oxygen demand structure permits coordinated contraction (acts as a syncytium) Cardiac myocytes do not regenerate Basic Cardiac Electrophysiology Ion Channels and Transporters in Cardiac Myocytes Cellular Adaptation Hypertrophic Cardiomyopathy Ischemic Injury Manifestations of Cardiac Dysfunction Arrhythmias (flutters, fibrillations) Cardiomyopathies Organism effects poor tissue oxygenation/perfusion (heart, other) accumulation of body fluids in inappropriate locations (lungs, abdominal cavity, legs) organ failure (kidney, liver, lungs) in the extreme …….death Measures of Toxicity:Alterations in Cardiovascular Function Physiologic function Electrocardiograms (EKG) most sensitive early indicator of cardiac toxicity Heart rate tail cuff method with photosensor (noninvasive) implanted telemetry devices Systemic arterial blood pressure/blood flow electromagnetic or doppler ultrasonic techniques Cardiac output transthoracic echocardiography Measures of Toxicity:Alterations in Cardiovascular Function Clinical Chemistry Electrolyte disturbances/imbalances sodium, potassium, calcium, magnesium, zinc Blood gas (acid/base balance) Proteins plasma albumin, myoglobin, fibrinogen Lipids plasma total cholesterol and triglycerides plasma lipoproteins, total lipids, phospholipids Measures of Toxicity:Alterations in Cardiovascular Structure Clinical Chemistry enzyme release (short half-life) creatine phosphokinase (CPK) hybrid dimer specific for cardiac muscle (CPK-MB) lactate dehydrogenase (LDH) ?-hydroxybutyrate dehydrogenase (?-HBDH) serum glutamic-oxaloacetic transaminase (SGOT, AST) Measures of Toxicity:Alterations in Cardiovascular Function Anatomic Pathology Direct cardiotoxicity Thrombosis infarction Inflammat