口腔干预对ACS合并牙周疾病患者心绞痛疗效观察.docVIP

口腔干预对ACS合并牙周疾病患者心绞痛疗效观察 　　[摘要]目的观察口腔专项干预改善急性冠脉综合征（ACS）合并牙周疾病患者心绞痛的疗效。方法将ACS合并中、重度慢性牙周疾病患者75例随机分为观察组（38例）和对照组（37例）。两组患者均接受常规抗ACS治疗，观察组另接受口腔专项干预，且分别在入选后3天内及干预6个月时进行疗效指标检测：①口腔及牙周健康指标；②外周血及龈沟液（GCF）处炎性标识指标（IL_1β、IL_6和TNF_α）；③心绞痛疗效问卷（西雅图心绞痛调查量表，SAQ）。结果干预前两组患者各类口腔及牙周相关指标接近，干预6个月后观察组的牙周袋深度（PD）、牙周附着丧失（CAL）、牙齿松动度（M）、龈沟出血指数（SBI）及简化口腔卫生指数（OHI_S）均明显好于干预前及对照组同期结果，差异有统计学意义（均P　　[关键词]急性冠脉综合征；牙周病；口腔干预；牙周健康指标 　　中图分类号：R541.4文献标识码：A文章编号：1009_816X（2014）05_0366_04 　　doi：10.3969/j.issn.1009_816x.2014.05.04Effects of Specialized Oral Intervention on Angina Treatment in Patients with ACS and Peridontal Disease. LI Ping， ZHANG Li， LI Anna， et al. Department of Cardiology， Shenyang 202 Hospital of Chinese PLA， Shenyang 110003， China 　　[Abstract] Objective To observe the effects of specialized oral intervention on angina treatment in patients with acute coronary syndrome （ACS ） and periodontal disease. Methods There were sequential 75 patients suffered with ACS and chronic periodontal disease， and they were randomly divided into 2 groups： Observation group （n=38） and contrast group （n=37）. Both groups accepted the conventional treatment and nursing care of anti_ACS， in addition， the observation group accepted specialized oral intervention. And the 2 groups were detected the healing effect indexes separately in 3 days and 6 months respectively： ① oral and periodontal health index，② peripheral blood and GCF inflammatory index（IL_1β， IL_6 and TNF_α， ③ questionnaire of anginal healing effect （Seattle angina symptoms questionnaire， SAQ）.Results The oral and periodontal indexes of both groups from the first detection are close， while after 6 months， the observation group had better indexes of PD， CAL， M， SBI and OHI_S， compared with its first detection and the indexes of contrast group in the same period， the difference is significant （P 　　[Key words] Acute Coronary Syndrome； Periodontal disease； Oral interventions； Periodontal health index 　　新近研究[1，2]显示，在冠心病（Coronary Heart Disease，CHD）或急性冠脉综合症（Acu