Mononucleosis Kardz Med传染性单核细胞增多症kardz医学ppt课件.pptVIP

Infectious Mononucleosis.;Infectious Mononucleosis (IM; also known as EBV infectious mononucleosis or glandular fever or Pfeiffers disease or Filatovs disease and sometimes colloquially as the kissing disease from its oral transmission or simply as mono in North America and as glandular fever in other English-speaking countries) is an infectious, widespread viral disease caused by the Epstein-Barr virus (EBV).;Infectious Mononucleosis : Cause;VIROLOGY.;Virology : Structure and Genome;Epidemiology : Incidence;Epidemiology : Seroprevalence;Primary EBV infection : Seroprevalence;Infectious MononucleosisTransmission;Epidemiology : Transmission; Pathophysiology ; Pathophysiology ; Pathophysiology ;Molecular Biology : Replication;Molecular Biology : Replication;Viral capsid antigens (VCAs);Molecular Biology : Latency;EBV generally transforms relatively mature B lymphocytes secreting a complete immunoglobulin product. EBV : infect and transform B cells in earlier stages of development (e.g. pre-B cells and lymphoid precusors lacking immunoglobulin gene rearrangement);Molecular Biology : EBV Subtype;Infectious Mononucleosis;Serum EBV antibodies;Serum Epstein-Barr Virus (EBV) Antibodies in EBV Infection;Symptoms.;;Lymphadenopathy : 90% symmetrical enlargement. mildly tender to palpation and not fix. posterior cervical lymph nodes. anterior cervical and submandibular nodes. axillary and inguinal nodes. Enlarged epitrochlear nodes are very suggestive of infectious mononucleosis. ;Hepatomegaly : 60% jaundice is rare. Percussion tenderness over the liver is common. Splenomegaly : 50% palpable 2-3 cm below the left costal margin and may be tender. rapidly over the first week of symptoms, usually decreasing in size over the next 7-10 days. spleen can rupture from relatively minor trauma or even spontaneously.;Maculopapular rash : 15% usually faint, widely scattered, and erythematous occurs in 3-15% of patients and is more common in young children. 80% of patients, tre