Seizures UCH Toxicology Program 2005药物诱导的癫痫发作这样的毒理学计划ppt课件.pptVIP

Drug-Induced Seizures;Definitions;Differential Diagnosis;Primary event direct reduction of seizure threshold Secondary event - cellular hypoxia caused by e.g. CO;Virtually any drug can cause seizure as a terminal event.;;;;Small-molecules Neurotransmitters and Neuropeptides ;;;Mechanisms;Mortality and Status Epilepticus;Drug Induced Seizures;GABAA Antagonism;GABAA Antagonism;Synergy (BDZ + Barb);GABA Antagonism;GABA Agonism;;Pyridoxine (B6) and GABA;Isoniazid;Isoniazid;Isoniazid;Pyridoxine Dosing;INH Induced Status Epilepticus;Adenosine;Adenosine;Adenosine;Theophylline;Theophylline;Theophylline Induced Seizures;Theophylline Induced Seizures;;;Strategy;Indication for charcoal Hemoperfusion/Hemodialysis;Indication for charcoal Hemoperfusion/Hemodialysis;Tricyclics;Tricyclics;Phenytoin and TCAs;;GABAA;Decreasing Alcohol Level Alcoholic Tremulousness Hypertension Tachycardia Hyperthermia Tremor Diaphoresis Delirium Tremens;Onset of Seizures;Number of Seizures;Time From First to Last Seizure;Chlordiazepoxide;Benzodiazepine Dosing;Role of Magnesium in Withdrawal;Haloperidol;Benzodiazepine Failures;Benzodiazepine Failures;Propofol;Phenytoin for Withdrawal Seizures;Problem Seizures;;聞到死;sodium dimercaptopropanesulfonateate DMPS succimer also useful for non-metalic pesticide -Tetramine;Bring home message: Think 3x before using phenytoin in treating all these drug-induced seizure Correct metabolic and electrolytes disturbances Decontamination ;;