抗体靶向治疗药物ppt课件.pptVIP

抗体靶向治疗药物 邵荣光 医药生物技术研究所;;;LYMPHOCYTE;Mechanism of Action: Monoclonal Ab;;Graphic representation of progression of monoclonal antibodies from murine to chimeric to humanized to PRIMATIZED? and human. The more human the antibody is, the less likely it will generate an immune response and the more utility it has for chronic (repeat) therapy.;;与单抗偶联的常用“弹头”药物;Physical characteristics of some therapeutic radionuclides;;;Monoclonal antibodies in the order of FDA-approval;US and EU therapeutic mAb approvals to date;1, chimeric mAbs, all products (n = 39); 2, oncological chimeric mAbs (n = 21); 3, imm