病毒的感染与致病机制课件.pptVIP

Chapter 21 The infection and pathogenic mechanism of virus;;Origin of viral infection ?Exogenous infection (1)?? patient (2)?? carrier (3) animal (zoonotic disease) ; The pathway of viral infection 1.? respiratory tract 2. digestive tract 3.?damaged skin or mucous membranes 4. blood 5.?arthropod vector 6. contact: sex contact (STD) ; The mode of viral infections horizontal transmission Viruses transmit from person-to-person or animal to person vertical transmission Viruses transmit from mother to offspring through placenta --- fetus, congenital infection, (congenital deformity) through birth canal --- infection of newborn through breast milk --- from virus-infected mothers ; The viruses which can result in congenital infection rubella virus (RV) cytomegalovirus (CMV) herpes simplex virus-I (HSV-I) hepatitis B virus (HBV) human immunodeficiency virus (HIV) ; ;congenital deformity (先天性畸形) caused by HCMV; Viral dissemination in vivo ? local infection ? systemic infection viremia ;; I. inapparent or subclinical infection viruses enter the body , but cause no apparent clinical syndrome. II. apparent infection or infectious disease. viruses enter the body ,which can cause apparent clinical syndrome. acute viral infection: viruses exist in the bodies for a short time (≦6 month) persistent viral infection: viruses exist in the bodies for a long time (＞6 month);persistent viral infection;HSV;The pathogenesis of viral infection ;cell;I. virus – cell interactions: 1. cytocidal infection virus which infect and replicate within cells causing the