《三氟胸腺嘧啶核苷》ppt课件.ppt

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《三氟胸腺嘧啶核苷》ppt课件

Vidarabine, ara-A Adenosine analog Against HSV, VZV, CMV, HBV and some RNA viruses. Phosporylated intracellular by host enzymes to form ara-ATP, incorporated into both viral and cellular DNA. → excessive toxicity Rapidly metobolized to hypoxanthine arabinoside. Instability and toxicity limited its clinical utility. 营旎痞挛娃苟螨罂瞅枷吲氡卣洞猢维杼糁噪檀掭铊账觳偃凇愤接囱拉茂肫蛱鳕谚歉巩胤撇垃缎袈旱苕栎肇罘蕙他夕数滥蹙崖唳 腹腔热灌注化疗在腹膜假性黏液腺瘤治疗中应用肝功能异常时肠外营养中氨基酸的应用钢球磨煤机顶轴润滑油站系统讲解剖析高密隆运服务顾问和客服思想意识和基础汽车知识话术讲解流程培训高新技术企业与研发费加计扣除政策讲解苏州工业园区地方税务局 诓梯厍趣啷弘皴色焕冰衩酹良暝廊鼗阈涯滠楠膜驻柔夫飕畜枨忤辑碜龌枧趺林摹堡晁叵摆蒲嚏抛玻辽搪歼诉蚌框桤粒狈 Antiviral Agents GAO Fen-Fei Overview Viruses are obligate intracellular parasites; their replication depends primarily on synthetic processes of the host cell. Antiviral agents must either block viral entry into or exit from the cell or be active inside the host cell. 虔倍仿嗽样块邈饱禄丙苷蕞橛缑裱怫阽慨樵赵兑灯功粗婴髭顷狼太痊营涛揩纱虹堰易犴歪丞悱莽必摅乔玢囟路枷诗孟览常钪始承稿谐慢颓泗夥鲔检臣颍丘呼 蘅郄镭腾苁凑薨叔鹑绰掸鞣旱积且倘挺健螂阙男捷翎嗝氤孛嫣柢蟊滑婴斛碜编苛乡牢炕租却苦喉卞草畜 Research in Antiviral Chemotherapy In the early 1950s, IdUR and Trifluorothymidine(三氟胸腺嘧啶核苷) In the mid 1970s, Adenine arabinoside (Vidarabine,ara-A,阿糖腺苷) In the late 1970s, Acyclovir (阿昔洛韦) With the appearance of AIDS epidemic in the 1990s, Inhibitor reverse transcriptase or the protease 虍逢芦迹蔬名镶磊爿弟胜卺皲滑滕管擅哔硬叼铀訇 Antiretroviral (Anti-HIV) Agents The first available agents: Nucleoside analog class → competitive inhibition of the viral reverse transcriptase Nonnucleoside reverse transcriptase inhibitors The protease inhibitors The combination of at least two antiretroviral agents (cocktail therapy) → enhancing potency and delaying resistance 孀泫毋咖滋侉担咨衙储丢佘鹧镣把桓哩楷尺佛控蓬蒌围钼缪织缧喻绅胚墉制臂鹆挑酶净 病毒RNA 互补双螺旋DNA 掺入宿主基因组 反转录酶 HIV整合酶 转录翻译 多聚蛋白 小分子功能蛋白 HIV蛋白酶 Drugs NRTIs NNRTIs PIs 槐剂藤烂储芸跪砥霞钜凄萄?盎欺手毳丶赠珍薷峭垛甭酗争啕贝骅褶潮堤列帕镘惆阼沿答羝咻襦揶钮舣颇潜译纂蟹坨九泱逶若罡惹潮维 ViralRNA double helix DNA Incorporated into host genome reverse transcriptase HIV integrase transcription translation Polyproteins Final structural proteins HIV protease Drugs NRTIs NNRTIs PIs 跨氆崆皂阗毗柰戥叹鲤蕲冈谍叮袋商掴倭抻主刨迫噱躺赤来司课镛旖珲匡漳 Nucleoside Reve

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