BMDOSTA和FRAX对绝经后骨质疏松症患者骨折预测价值分析.docVIP

BMDOSTA和FRAX对绝经后骨质疏松症患者骨折预测价值分析 　　【摘要】 目的：探讨BMD、OSTA和FRAX对绝经后女性骨质疏松症患者骨折的预测价值。方法：选择2014年1-12月在本院诊断的70例严重骨质疏松女性患者作为研究对象，根据患者是否发生骨折分为骨折组18例和非骨折组52例，比较两组患者的骨密度、骨转换指标以及FRAX结果。结果：骨折组患者BMD水平（-3.9±0.6）显著低于未骨折组，OSTA评分（-1.1±0.4）分显著低于未骨折组，而FRAX指数（5.8±1.1）显著高于未骨折组，比较差异均有统计学意义（P0.01）。FRAX联合BMD对骨折风险的预测价值最高，OSTA相对较差。结论：老年女性骨质疏松症发生骨折患者骨密度、OSTA评分显著低于未骨折患者，而FRAX指数显著高于未骨折患者，进一步分析，FRAX指数联合BMD对女性骨质疏松症患者骨折的预测准确性最高。 　　【关键词】 骨密度； 亚洲骨质疏松自我评估工具； 骨折风险因子评估工具； 骨质疏松症； 骨折 　　【Abstract】 Objective：To investigate the predictive value of BMD，OSTA and FRAX for fractures of postmenopausal women with osteoporosis.Method：Seventy female patients with severe osteoporosis who were diagnosed in our hospital from January 2014 to December 2014 were selected as research objects，they were divided into the fracture group for 18 cases and non fracture group for 52 cases according to whether patients with fracture.BMD，OSTA and FRAX of the two groups were compared.Result：BMD of the fracture group was（-3.9±0.6），which was significantly lower than that of the non fracture group，OSTA of the fracture group was （-1.1±0.4）scores，which was significantly lower than that of the non fracture group，FRAX of the fracture group was（5.8±1.1），which was significantly higher than that of the non fracture group，the differences were statistically significant（P0.01）.FRAX combined with BMD showed the highest value for prediction of fracture risk，and OSTA was relatively poor.Conclusion：BMD and OSTA of postmenopausal osteoporosis with fracture are lower than patients without fracture，and FRAX is higher.Further analysis，the prediction accuracy of FRAX combined with BMD for fractures of postmenopausal women with osteoporosis is the highest. 　　【Key words】 BMD； OSTA； FRAX； Osteoporosis； Fracture 　　First-author’s address：Traditional Chinese Medicine Hospital of Foshan City，Foshan 528000，China 　　doi：10.3969/j.issn.1674-4985.2016.02.014 　　老年人容易发生骨质疏松症，尤其是绝经后女性，主要表现为骨量下降，骨微结构遭到破坏，骨脆性增加，容易发生骨折。骨密度是目前临床上诊断骨质疏松的有效指标，但其对骨质疏松患者骨折风险的关系存在争议[1]。OST