NSE及IGF―1在癫痫发作患儿血清中表达及临床意义.docVIP

NSE及IGF―1在癫痫发作患儿血清中表达及临床意义 　　[摘要] 目的 更进一步对NSE及IGF-1在癫痫发作患儿血清中的临床表达及其临床意义进行探究。方法 方便择取2015年7月―2017年7月于该院儿科接受治疗的120例癫痫发作患儿进行回顾分析，设为观察组，另取120名健康儿童作为对照研究，设为对照组。对两组儿童均行ELISA及放射免疫分析法进行探究，对比两组研究儿童NSE及IGF-1在血清中的表达差异。结果 结果显示，对照组儿童IGF-1、NSE分别为（14.48±2.13）μmol/L、（7.11±1.19）μg/L，观察组患者对应数据为（8.82±2.96）μmol/L、（20.35±8.91）μg/L，可见，对照组IGF-1、NSE表达与观察组比较差异有统计学意义，经Pearson相关分析发现，癫痫发作期患儿血清中NSE及IGF-1二者的表达变化间呈明显的正相关（r=0.86，P0.05）；观察组平行联合检测阳性为16例，系列联合检测阳性为0例，尽管平行联合检测灵敏度高于系列?合检测，但系列联合检测的准确度、特异性均明显高于平行联合检测，差异有统计学意义（P0.05）。结论 对于癫痫患儿的诊断，检测其体内NSE及IGF-1二者联合浓度表达情况具有高敏感性与特异性，值得推广应用。 　　[关键词] 血清；NSE；癫痫发作；儿童；IGF-1；ELISA；放射免疫法 　　[中图分类号] R446 [文献标识码] A [文章编号] 1674-0742（2018）01（a）-0037-03 　　Expression and Clinical Significance of NSE and IGF-1 in Serum of Epileptic Children 　　NI Guang 　　Department of Inner Medicine， Section Two， Qingshui Country Hospital，Qingshui， Gansu Province，741400 China 　　[Abstract] Objective This paper tries to further explore the NSE and IGF-1 in serum of children with clinical expression and its clinical significance in epilepsy research. Methods 120 cases of pediatric epilepsy patients were retrospectively analyzed from July 2015 to July 2017 as the observation group， another 120 cases of healthy children were convenient selected as control group. The two groups of children were tested by ELISA and radioimmunoassay， compared two groups of children’s NSE and IGF-1 in serum expression differences. Results The results showed that the patients in the control group IGF-1， NSE was （14.48±2.13）μmol/L， （7.11±1.19）μg/L， the corresponding data of patients in the observation group were （8.82±2.96）μmol/L， （20.35±8.91）μg/L， the control group IGF-1， the expression of NSE and the observation group had significant difference， the Pearson correlation analysis found that seizures were significantly and positively related to the expression changes of NSE and IGF-1 in serum of children with stage two the room （r=0.86， P 　　[Key words] Serum； NSE； Epilepsy； Children； IGF-1； ELISA； Radioimmunoa