α干扰素治疗小儿水痘临床疗效评价.docVIP

α干扰素治疗小儿水痘临床疗效评价 　　【摘要】 目的 评价α干扰素治疗小儿水痘的疗效及安全性,探索有效的治疗方法。方法 采用多中心、随机、对照研究方法。对象为儿科门诊年龄在1～9岁之间、病程在48 h内的水痘患儿68例,随机分为两组,对照组34例,予以利巴韦林肌肉注射;治疗组34例,给予α干扰素,10万U/(kg#8226;d),肌肉注射,疗程为3～5 d。对两组临床疗效进行比较。结果 治疗组显效率61.8%,明显高于对照组的47.1%;而治疗组退热时间为(1.76±1.23)d,对照组为(2.46±1.65)d。两组比较对照组在显效率和退热时间上均与对照组具有统计学差异(P0.05)。结论 α干扰素可缩短退热时间,改善水痘患儿临床症状及提高疗效,是一有效、安全的治疗小儿水痘药物。 　　【关键词】 α干扰素;小儿;水痘 　　 　　To evaluate the efficiency of interferonα in the treatment of children with Varicella 　　QIN Zhangping. 　　Department of pediatrics,The People’s Hospital of Cili County, Zhangjiajie, Hunan 427200,China 　　【Abstract】 Objective To evaluate the efficacy and safety of interferonα in the treatment of children with varicella and to Explore the effective treatment. Methods A multicentra, randomized and controlled trial was conducted in 68 childrens aged from 1 to 9 years,had mild to moderate diarrhea of less than 48 houres duration.Totally children with varicella were divided into two groups randomly. There were 34 cases in the control group,the patients intramuscular injection Ribavirin. There were 34 cases in the treatment group, the patients intramuscular injection Interferonα. The total therapeutic course were 3～5 days. Comparative analysis for two groups. Results The dominant effective rate was 61.8% in the treatment group, the antipyretic time was (1.76±1.23 d); The control group was 47.1% and(2.46±1.65)d. There was a significant difference between two group(P0.01). Conclusion Interferonα can shorten the antipyretic time and improve clinical symptoms and enhance the effectiveness of children with varicella, it is a effective and safety drug for the treatment of children with varicella. 　　【Key words】 Interferonα; Children; Varicella 　　 　　小儿水痘系水痘带状疱疹病毒(varicella zoster virus,VZV)所致,具很强传染性,主要传染途径为呼吸道飞沫和直接接触。主要侵犯学龄前儿童和婴幼儿,临床症状表现为低热、针头大小的斑疹、疱壁较薄易破内有脓液,会伴发继发细菌感染及水痘肺炎等,严重影响了婴幼儿的身体健康。干扰素是一种高活性、高效应的诱生蛋白质,具有广谱的抗病毒和免疫调节等多种生物活性作用。本研究采用随机对照的方法,于2004年5月至2007年5月间对门诊水痘患儿采用α干扰素进行治疗,探讨α干扰素治疗小儿水痘的作用机制及临床应用的可能性,结果取得