PTEN基因与肿瘤抑制蛋白p53在子宫内膜癌组织中表达及临床意义.docVIP

PTEN基因与肿瘤抑制蛋白p53在子宫内膜癌组织中表达及临床意义 　　[摘要] 目的 探讨PTEN基因与肿瘤抑制蛋白p53在子宫内膜癌组织中的表达及其临床意义。 方法 选取本院2013年7月～2015年6月的52例子宫内膜癌组织作为观察组，选取55例正常子宫内膜组织作为对照组，采用免疫组织化学技术检测两组的PTEN基因以及肿瘤抑制蛋白p53表达情况，并分析其与不同国际妇产科联盟（FIGO）分期、细胞分化程度及有无淋巴结转移的关系。 结果 观察组的PTEN基因阳性表达率显著低于对照组，肿瘤抑制蛋白p53的阳性表达率显著高于对照组，差异有统计学意义（P0.05）。PTEN基因的表达与FIGO分期、细胞分化程度及淋巴结转移有关（P0.05）。肿瘤抑制蛋白p53的表达与FIGO分期及淋巴结转移有关（P0.05）。 结论 PTEN基因与肿瘤抑制蛋白p53在子宫内膜癌组织中的表达异常，其在肿瘤的发生、发展过程中起着重要作用。 　　[关键词] PTEN基因；肿瘤抑制蛋白p53；子宫内膜癌；表达；临床意义 　　[中图分类号] R737.33 [文献标识码] A [文章编号] 1674-4721（2016）03（b）-0058-03 　　[Abstract] Objective To explore the expression and clinical significance of PTEN gene and tumor suppressor protein p53 in endometrial carcinoma tissue. Methods 52 cases of endometrial cancer tissue from July 2013 to June 2015 were selected as the observation group，55 cases of normal endometrial tissue were selected as the control group.The expression condition of PTEN gene and tumor suppressor protein p53 in the two groups were detected by immunohistochemical technique.The relationship between them and the FIGO staging，differentiation degree and lymph node metastasis were analyzed. Results The positive expression rate of PTEN gene in the observation group was lower than that in the control group，the positive expression rate of tumor suppressor protein p53 in the observation gruoup was higher than that in the control group，with significant difference （P0.05）.The expression of PTEN gene was related to FIGO stage，differentiation degree and lymph node metastasis （P0.05）.The expression of tumor suppressor protein p53 was related to FIGO stage and lymph node metastasis （P0.05）. Conclusion The expression of PTEN gene and tumor suppressor protein p53 in endometrial carcinoma is abnormal，which plays an important role in the occurrence and development of cancer. 　　[Key words] PTEN gene；Tumor suppressor protein p53；Endometrial cancer；Expression；Clinical significance 　　子宫内膜癌是常见的女性生殖系统恶性疾病之一，近年来其发病率呈现逐渐增高的趋势，且趋于年轻化[1-3]。子宫内膜癌早期即可发生浸润、转移，对患者的生活质量及预后造成严重影响[4]。其临床分期、